Pre-discharge F-Flourodeoxyglucose Uptake Pattern Following Transcatheter Aortic-valve Replacement and Adverse Prognostic Features in Aortic Stenosis

Overview

Journal Indian Heart J

Publisher Elsevier

Specialty Cardiology & Vascular Diseases

Date 2023 Aug 11

PMID 37567445

Authors

Baskaran Chandrasekar

Satish Panchadar

Khaled Almerri

Masoud Garashi

Affiliations

Soon will be listed here.

Abstract

F-Flourodeoxyglucose positron emission tomography/computed tomography (F-FDG-PET/CT) has been shown to be of utility in transcatheter aortic valve replacement (TAVR) patients with suspected prosthetic valve endocarditis. In the present study, we sought to analyze the relationship between F-FDG-PET/CT performed before discharge in TAVR patients and adverse prognostic features of aortic stenosis. We analyzed the association between F-FDG-PET/CT uptake pattern and degree of left ventricular mass index, aortic root dilatation, and aortic leaflet calcification extent. This is the first study to demonstrate that pre-discharge F-FDG-PET/CT in patients undergoing TAVR shows a significant negative correlation between F-FDG uptake pattern and adverse prognostic features.

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A computer vision model for the identification and scoring of calcium in aortic valve stenosis: a single-center experience.

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PMID: 39790210 PMC: 11707472. DOI: 10.21037/cdt-24-179.

References

Del Val D, Trottier M, Alperi A, Muntane-Carol G, Faroux L, DeLarochelliere R . F-Fluorodeoxyglucose Uptake Pattern in Noninfected Transcatheter Aortic Valves. Circ Cardiovasc Imaging. 2020; 13(11):e011749. DOI: 10.1161/CIRCIMAGING.120.011749. View

Leber A, Kasel M, Ischinger T, Ebersberger U, Antoni D, Schmidt M . Aortic valve calcium score as a predictor for outcome after TAVI using the CoreValve revalving system. Int J Cardiol. 2011; 166(3):652-7. DOI: 10.1016/j.ijcard.2011.11.091. View

Patel P, El Sabbagh A, Johnson P, Suliman R, Salwa N, Morales-Lara A . Sex Differences in the Impact of Aortic Valve Calcium Score on Mortality After Transcatheter Aortic Valve Replacement. Circ Cardiovasc Imaging. 2022; 15(8):e014034. PMC: 9397521. DOI: 10.1161/CIRCIMAGING.122.014034. View

Rudd J, Myers K, Bansilal S, Machac J, Woodward M, Fuster V . Relationships among regional arterial inflammation, calcification, risk factors, and biomarkers: a prospective fluorodeoxyglucose positron-emission tomography/computed tomography imaging study. Circ Cardiovasc Imaging. 2009; 2(2):107-15. PMC: 3190196. DOI: 10.1161/CIRCIMAGING.108.811752. View

San S, Abulizi M, Moussafeur A, Oliver L, Lepeule R, Nahory L . Characterization of 18-Fluorodeoxyglucose Uptake Pattern in Infective Endocarditis After Transcatheter Aortic Valve Implantation. JACC Cardiovasc Imaging. 2018; 12(5):930-932. DOI: 10.1016/j.jcmg.2018.10.018. View

Jenkins W, Vesey A, Shah A, Pawade T, Chin C, White A . Valvular (18)F-Fluoride and (18)F-Fluorodeoxyglucose Uptake Predict Disease Progression and Clinical Outcome in Patients With Aortic Stenosis. J Am Coll Cardiol. 2015; 66(10):1200-1. DOI: 10.1016/j.jacc.2015.06.1325. View

Salaun E, Sportouch L, Barral P, Hubert S, Lavoute C, Casalta A . Diagnosis of Infective Endocarditis After TAVR: Value of a Multimodality Imaging Approach. JACC Cardiovasc Imaging. 2017; 11(1):143-146. DOI: 10.1016/j.jcmg.2017.05.016. View

Wykrzykowska J, Lehman S, Williams G, Parker J, Palmer M, Varkey S . Imaging of inflamed and vulnerable plaque in coronary arteries with 18F-FDG PET/CT in patients with suppression of myocardial uptake using a low-carbohydrate, high-fat preparation. J Nucl Med. 2009; 50(4):563-8. DOI: 10.2967/jnumed.108.055616. View

Aksoy O, Cam A, Agarwal S, Ige M, Yousefzai R, Singh D . Significance of aortic valve calcification in patients with low-gradient low-flow aortic stenosis. Clin Cardiol. 2013; 37(1):26-31. PMC: 6649593. DOI: 10.1002/clc.22212. View

10.

Makkar R, Thourani V, Mack M, Kodali S, Kapadia S, Webb J . Five-Year Outcomes of Transcatheter or Surgical Aortic-Valve Replacement. N Engl J Med. 2020; 382(9):799-809. DOI: 10.1056/NEJMoa1910555. View

11.

Ishimaru S, Tsujino I, Takei T, Tsukamoto E, Sakaue S, Kamigaki M . Focal uptake on 18F-fluoro-2-deoxyglucose positron emission tomography images indicates cardiac involvement of sarcoidosis. Eur Heart J. 2005; 26(15):1538-43. DOI: 10.1093/eurheartj/ehi180. View

12.

Agmon Y, Khandheria B, Meissner I, Sicks J, OFallon W, Wiebers D . Aortic valve sclerosis and aortic atherosclerosis: different manifestations of the same disease? Insights from a population-based study. J Am Coll Cardiol. 2001; 38(3):827-34. DOI: 10.1016/s0735-1097(01)01422-x. View

13.

Marincheva-Savcheva G, Subramanian S, Qadir S, Figueroa A, Truong Q, Vijayakumar J . Imaging of the aortic valve using fluorodeoxyglucose positron emission tomography increased valvular fluorodeoxyglucose uptake in aortic stenosis. J Am Coll Cardiol. 2011; 57(25):2507-15. DOI: 10.1016/j.jacc.2010.12.046. View

14.

Habib G, Lancellotti P, Antunes M, Bongiorni M, Casalta J, Del Zotti F . 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the.... Eur Heart J. 2015; 36(44):3075-3128. DOI: 10.1093/eurheartj/ehv319. View

15.

Ochiai T, Yoon S, Sharma R, Miyasaka M, Maeno Y, Raschpichler M . Prevalence and Prognostic Impact of Ascending Aortic Dilatation in Patients Undergoing TAVR. JACC Cardiovasc Imaging. 2019; 13(1 Pt 1):175-177. DOI: 10.1016/j.jcmg.2019.07.025. View

16.

Gonzales H, Douglas P, Pibarot P, Hahn R, Khalique O, Jaber W . Left Ventricular Hypertrophy and Clinical Outcomes Over 5 Years After TAVR: An Analysis of the PARTNER Trials and Registries. JACC Cardiovasc Interv. 2020; 13(11):1329-1339. DOI: 10.1016/j.jcin.2020.03.011. View

17.

Duncan A, Ludman P, Banya W, Cunningham D, Marlee D, Davies S . Long-term outcomes after transcatheter aortic valve replacement in high-risk patients with severe aortic stenosis: the U.K. Transcatheter Aortic Valve Implantation Registry. JACC Cardiovasc Interv. 2015; 8(5):645-53. DOI: 10.1016/j.jcin.2015.01.009. View