Microglia-Astrocyte Interaction in Neural Development and Neural Pathogenesis

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2023 Aug 11

PMID 37566021

Authors

Meiqi Sun

Hongli You

Xiaoxuan Hu

Yujia Luo

Zixuan Zhang

Yiqun Song

Jing An

Haixia Lu

Affiliations

Soon will be listed here.

Abstract

The interaction between microglia and astrocytes exhibits a relatively balanced state in order to maintain homeostasis in the healthy central nervous system (CNS). Disease stimuli alter microglia-astrocyte interaction patterns and elicit cell-type-specific responses, resulting in their contribution to various pathological processes. Here, we review the similarities and differences in the activation modes between microglia and astrocytes in various scenarios, encompassing different stages of neural development and a wide range of neural disorders. The aim is to provide a comprehensive understanding of their roles in neural development and regeneration and guiding new strategies for restoring CNS homeostasis.

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