Harnessing Developmental Cues for Cardiomyocyte Production

Overview

Journal Development

Specialty Biology

Date 2023 Aug 10

PMID 37560977

Authors

Renee G C Maas

Floor W van den Dolder

Qianliang Yuan

Jolanda van der Velden

Sean M Wu

Joost P G Sluijter

Jan W Buikema

Affiliations

Soon will be listed here.

Abstract

Developmental research has attempted to untangle the exact signals that control heart growth and size, with knockout studies in mice identifying pivotal roles for Wnt and Hippo signaling during embryonic and fetal heart growth. Despite this improved understanding, no clinically relevant therapies are yet available to compensate for the loss of functional adult myocardium and the absence of mature cardiomyocyte renewal that underlies cardiomyopathies of multiple origins. It remains of great interest to understand which mechanisms are responsible for the decline in proliferation in adult hearts and to elucidate new strategies for the stimulation of cardiac regeneration. Multiple signaling pathways have been identified that regulate the proliferation of cardiomyocytes in the embryonic heart and appear to be upregulated in postnatal injured hearts. In this Review, we highlight the interaction of signaling pathways in heart development and discuss how this knowledge has been translated into current technologies for cardiomyocyte production.

Citing Articles

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