An MRI-based Scoring System for Pretreatment Risk Stratification in Locally Advanced Rectal Cancer

Overview

Journal Br J Cancer

Specialty Oncology

Date 2023 Aug 9

PMID 37558922

Authors

Minning Zhao

Lili Feng

Ke Zhao

Yanfen Cui

Zhenhui Li

Chenglu Ke

Xinyue Yang

Qing Qiu

Weirong Lu

Yanting Liang

Chuanmiao Xie

Xiangbo Wan

Zaiyi Liu

Affiliations

Soon will be listed here.

Abstract

Background: Accurately assessing the risk of recurrence in patients with locally advanced rectal cancer (LARC) before treatment is important for the development of treatment strategies. The purpose of this study is to develop an MRI-based scoring system to predict the risk of recurrence in patients with LARC.

Methods: This was a multicenter observational study that enrolled participants who underwent neoadjuvant chemoradiotherapy. To evaluate the risk of recurrence in these patients, we developed the mrDEC scoring system and assessed inter-reader agreement. Additionally, we plotted Kaplan-Meier curves to compare the 3-year disease-free survival (DFS) and 5-year overall survival (OS) rates among patients with different mrDEC scores.

Results: A total of 1287 patients with LARC were included in this study. We observed substantial inter-reader agreement for mrDEC. Based on the mrDEC scores ranging from 0 to 3, the patients were categorized into four groups. The 3-year DFS rates for the groups were 91.0%, 79.5%, 65.5%, and 44.0% (P < 0.0001), respectively, and the 5-year OS rates were 92.9%, 87.1%, 74.8%, and 44.5%, respectively (P < 0.0001).

Conclusions: The mrDEC scoring system proved to be an effective tool for predicting the prognosis of patients with LARC and can assist clinicians in clinical decision-making.

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