Does the Use of Oral Contraceptives or Hormone Replacement Therapy Offer Protection Against the Formation or Rupture of Intracranial Aneurysms in Women?: a Systematic Review and Meta-analysis

Overview

Journal Rev Assoc Med Bras (1992)

Specialty General Medicine

Date 2023 Aug 9

PMID 37556637

Authors

Diana Lara Pinto de Santana

Mariangela Barbi Goncalves

Vanessa Milanese Holanda Zimpel

Eberval Gadelha Figueiredo

Affiliations

Soon will be listed here.

Abstract

Objective: The aim of this study was to carry out a systematic review of the literature with meta-analysis to evaluate the effect of using oral contraceptive and hormone replacement therapy as a protective factor in the formation of intracranial aneurysms and subarachnoid hemorrhage.

Methods: This is a systematic review of the literature with meta-analysis, using PubMed and Embase as databases and the PRISMA method. Case-control and cohort studies published until December 2022 were included in this review.

Results: Four studies were included in this review; three of which were eligible for meta-analysis. Regarding the use of oral contraceptive and the development of subarachnoid hemorrhage, there was a lower risk of aneurysm rupture with an odds ratio 0.65 (confidence interval 0.5-0.85). In the analysis of patients using hormone replacement therapy and developing subarachnoid hemorrhage, there was also a lower risk of aneurysm rupture with an OR 0.54 (CI 0.39-0.74). Only one article analyzed the formation of intracranial aneurysm and the use of hormone replacement therapy and oral contraceptive, and there was a protective effect with the use of these medications. oral contraceptive: OR 2.1 (CI 1.2-3.8) and hormone replacement therapy: OR 3.1 (CI 1.5-6.2).

Conclusion: The use of hormone replacement therapy and oral contraceptive has a protective effect in intracranial aneurysm rupture and formation.

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