Fenugreek Seed Powder Protects Mice Against Arsenic-induced Neurobehavioral Changes

Overview

Journal Curr Res Toxicol

Specialty Biology

Date 2023 Aug 9

PMID 37554151

Authors

Jahidul Islam

Zohurul Islam

Nazmul Haque

Moriom Khatun

Farhadul Islam

Shakhawoat Hossain

Md Ashraful Hoque

Farjana Nikkon

Khaled Hossain

Zahangir Alam Saud

Affiliations

Soon will be listed here.

Abstract

The current study was designed to evaluate the protective effect of fenugreek seed powder against As-induced neurobehavioral and biochemical perturbations using a mouse model. Mice exposed to arsenic at 10 mg/kg body weight showed development of anxiety-like behavior and memory impairment compared to control mice in elevated plus maze and Morris water maze tests, respectively. A significantly decreased acetyl and butyrylcholinesterase, superoxide dismutase and glutathione reductase activities and brain-derived neurotrophic factor levels were found in the brain of arsenic-exposed mice compared to control mice. Interestingly, supplementation of fenugreek seed powder to arsenic-treated mice significantly restored the activity of cholinesterase and antioxidant enzymes ( superoxide dismutase, glutathione reductase) as well as brain-derived neurotrophic factor levels in the brain tissue of arsenic-exposed mice. Consequently, reduced anxiety-like behavior, improved learning and memory were observed in fenugreek supplemented arsenic treated mice compared to only arsenic-exposed mice group. Thus, this study suggests that fenugreek seed powder reduces arsenic-induced neurotoxicity in mice.

Citing Articles

Combined Effects of Arsenic and Bisphenol-A on Locomotor Activity and Oxidative Stress Mediated Neurotoxicity in Mice.

Beauty S, Hossain J, Sarder S, Uddin N, Goni O, Abedin F Biol Trace Elem Res. 2025; .

PMID: 39853653 DOI: 10.1007/s12011-025-04522-3.

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