Alpha 2.0
Login Register
» Articles » PMID: 37551206

Eyelid and Vaginal Adhesions As Severe Sequelae of Toxic Epidermal Necrolysis

Overview
Journal Cureus
Specialty Biomedical Engineering
Date 2023 Aug 8
PMID 37551206
Authors
Kaori Suzuki
Yuko Watanabe
Yuichi Imai
Yukie Yamaguchi
Affiliations
Soon will be listed here.
Abstract

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are mucocutaneous diseases featured by severe sequelae and high mortality rates. In addition to ocular involvement, gynecological involvement is often observed in patients with TEN with possible occurrence of partial or complete adhesions of the labia majora, labia minora, and vaginal walls as severe sequelae. Although the gynecological sequelae of TEN severely affect patients' quality of life, there is a lack of awareness among medical professionals. Moreover, preventive measures and the effectiveness of treatment have not yet been fully verified. Herein, we describe a case of TEN with severe sequelae of eyelid and vaginal adhesions.

References
1.
Jongkhajornpong P, Lekhanont K, Pisuchpen P, Chantaren P, Puangsricharern V, Prabhasawat P . Association between HLA-B*44:03-HLA-C*07:01 haplotype and cold medicine-related Stevens-Johnson syndrome with severe ocular complications in Thailand. Br J Ophthalmol. 2018; 102(9):1303-1307. DOI: 10.1136/bjophthalmol-2017-311823. View
2.
Ueta M, Kaniwa N, Sotozono C, Tokunaga K, Saito Y, Sawai H . Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement. Sci Rep. 2014; 4:4862. PMC: 5381277. DOI: 10.1038/srep04862. View
3.
Kaser D, Reichman D, Laufer M . Prevention of vulvovaginal sequelae in stevens-johnson syndrome and toxic epidermal necrolysis. Rev Obstet Gynecol. 2011; 4(2):81-5. PMC: 3218548. View
4.
Meneux E, Wolkenstein P, Haddad B, Roujeau J, Revuz J, Paniel B . Vulvovaginal involvement in toxic epidermal necrolysis: a retrospective study of 40 cases. Obstet Gynecol. 1998; 91(2):283-7. DOI: 10.1016/s0029-7844(97)00596-6. View
5.
Sotozono C, Ueta M, Nakatani E, Kitami A, Watanabe H, Sueki H . Predictive Factors Associated With Acute Ocular Involvement in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Am J Ophthalmol. 2015; 160(2):228-237.e2. DOI: 10.1016/j.ajo.2015.05.002. View