Non-additive Genetic Components Contribute Significantly to Population-wide Gene Expression Variation

Overview

Journal bioRxiv

Date 2023 Aug 7

PMID 37546809

Authors

Andreas Tsouris

Gauthier Brach

Joseph Schacherer

Jing Hou

Affiliations

Soon will be listed here.

Abstract

Gene expression variation, an essential step between genomic variation and phenotypic landscape, is collectively controlled by local () and distant () regulatory changes. Nevertheless, how these regulatory elements differentially influence the heritability of expression traits remains unclear. Here, we bridge this gap by analyzing the transcriptomes of a large diallel panel consisting of 323 unique hybrids originated from genetically divergent yeast isolates. We estimated the broad- and narrow-sense heritability across 5,087 transcript abundance traits and showed that non-additive components account for 36% of the phenotypic variance on average. By comparing allelic expression ratios in the hybrid and the corresponding parental pair, we identified regulatory changes in 25% of all cases, with a majority acting in . We further showed that regulation could underlie coordinated expression variation across highly connected genes, resulting in significantly higher non-additive variance and most likely in some of the missing heritability of gene expression traits.

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