Prenatal Exposure to Perfluoroalkyl Substances and Inflammatory Biomarker Concentrations

Overview

Journal Environ Epidemiol

Publisher Wolters Kluwer

Specialty Environmental Health

Date 2023 Aug 7

PMID 37545803

Authors

Jana Palaniyandi

Jennifer E Bruin

Premkumari Kumarathasan

Susan MacPherson

Michael M Borghese

Jillian Ashley-Martin

Affiliations

Soon will be listed here.

Abstract

Methods: We analyzed data from 1411 participants, recruited between 2008 and 2011, in the Maternal-Infant Research on Environmental Chemicals study. Our primary outcome was a composite inflammatory index derived by summing the z-scores of eight proinflammatory biomarkers. Using multivariable linear regression models, we quantified associations between each PFAS and the inflammatory index and individual biomarkers. We quantified the effects of the PFAS mixture using weighted quantile sum regression, and evaluated effect modification using product terms and sex-stratified models.

Results: Each doubling of PFOA and PFHxS was associated with a 0.38 (95% CI, 0.09, 0.67) and 0.21 (95% CI, 0.01, 0.41) SD increase in the proinflammatory index, respectively. A one-quartile increase in the PFAS mixture was associated with a 0.40 (95% CI, 0.09, 0.71) SD increase in the proinflammatory index. In individual models, we observed positive associations between PFAS and concentrations of monocyte chemoattractant protein-1, macrophage inflammatory protein-1β, and matrix metalloproteinases-9; however, the magnitude and precision varied according to the specific PFAS. Sex-specific findings were identified in few PFAS-biomarker associations.

Conclusions: PFOA, PFOS, and PFHxS, individually and as a mixture, were positively associated with proinflammatory biomarkers during pregnancy.

Citing Articles

Associations between per-and polyfluoroalkyl substances (PFAS) and county-level cancer incidence between 2016 and 2021 and incident cancer burden attributable to PFAS in drinking water in the United States.

Li S, Oliva P, Zhang L, Goodrich J, McConnell R, Conti D J Expo Sci Environ Epidemiol. 2025; .

PMID: 39789195 DOI: 10.1038/s41370-024-00742-2.

Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and their influence on inflammatory biomarkers in pregnancy: Findings from the LIFECODES cohort.

Siwakoti R, Harris S, Ferguson K, Hao W, Cantonwine D, Mukherjee B Environ Int. 2024; 194:109145.

PMID: 39550829 PMC: 11663107. DOI: 10.1016/j.envint.2024.109145.

Association between a Mixture of Per- and Polyfluoroalkyl Substances (PFAS) and Inflammatory Biomarkers in the Atlanta African American Maternal-Child Cohort.

Tan Y, Taibl K, Dunlop A, Barr D, Panuwet P, Yakimavets V Environ Sci Technol. 2023; 57(36):13419-13428.

PMID: 37649345 PMC: 10900195. DOI: 10.1021/acs.est.3c04688.

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