Characteristics of Gram-positive Cocci Infection and the Therapeutic Effect After Liver Transplantation

Overview

Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban

Specialty General Medicine

Date 2023 Aug 4

PMID 37539573

Authors

Xiaoxia Wu

Lingli Wu

Lin Shu

Chenpeng Xie

Qiquan Wan

Affiliations

Soon will be listed here.

Abstract

Objectives: Gram-positive cocci is the main pathogen responsible for early infection after liver transplantation (LT), posing a huge threat to the prognosis of liver transplant recipients. This study aims to analyze the distribution and drug resistance of Gram-positive cocci, the risk factors for infections and efficacy of antibiotics within 2 months after LT, and to guide the prevention and treatment of these infections.

Methods: In this study, data of pathogenic bacteria distribution, drug resistance and therapeutic efficacy were collected from 39 Gram-positive cocci infections among 256 patients who received liver transplantation from donation after citizens' death in the Third Xiangya Hospital of Central South University from January 2019 to July 2022, and risk factors for Gram-positive cocci infection were analyzed.

Results: was the dominant pathogenic bacteria (33/51, 64.7%), followed by (11/51, 21.6%). The most common sites of infection were abdominal cavity/biliary tract (13/256, 5.1%) and urinary tract (10/256, 3.9%). Fifty (98%) of the 51 Gram-positive cocci infections occurred within 1 month after LT. The most sensitive drugs to Gram-positive cocci were teicoplanin, tigecycline, linezolid and vancomycin. Vancomycin was not used in all patients, considering its nephrotoxicity. Vancomycin was not administered to all patients in view of its nephrotoxicity.There was no significant difference between the efficacy of daptomycin and teicoplanin in the prevention of cocci infection (>0.05). Univariate analysis indicated that preoperative Model for End-Stage Liver Disease (MELD) score >25 (=0.005), intraoperative red blood cell infusion ≥12 U (=0.013) and exposure to more than 2 intravenous antibiotics post-LT (=0.003) were related to Gram-positive cocci infections. Multivariate logistic regression analysis revealed that preoperative MELD score >25 (=2.378, 95% 1.124 to 5.032, =0.024) and intraoperative red blood cell transfusion ≥ 12 U (=2.757, 95% 1.227 to 6.195, =0.014) were independent risk factors for Gram-positive cocci infections after LT. Postoperative Gram-positive cocci infections were reduced in LT recipients exposing to more than two intravenous antibiotics post-LT (=0.269, 95% 0.121 to 0.598, =0.001).

Conclusions: Gram-positive cocci infections occurring early after liver transplantation were dominated by infections at the abdominal/biliary tract and urinary tract. Teicoplanin, tigecycline and linezolid were anti-cocci sensitive drugs. Daptomycin and teicoplanin were equally effective in preventing cocci infections due to Gram-positive cocci. Patients with high preoperative MELD score and massive intraoperative red blood cell transfusion were more likely to suffer Gram-positive cocci infection after surgery. Postoperative Gram-positive cocci infections were reduced in recipients exposing to more than two intravenous antibiotics post-LT.

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