Phenotyping the Obesities: Reality or Utopia?

Overview

Journal Rev Endocr Metab Disord

Publisher Springer

Specialty Endocrinology

Date 2023 Aug 3

PMID 37537402

Authors

Piero Portincasa

Gema Fruhbeck

Affiliations

Soon will be listed here.

Abstract

In this thematic issue on phenotyping the obesities, prominent international experts offer an insightful and comprehensive collection of articles covering the current knowledge in the field. In order to actually capture all the polyhedral determinants of the diverse types of obesity, the granularity of the phenotypic information acquired must be expanded in the context of a personalized approach. Whilst the use of precision medicine has been successfully implemented in areas like cancer and other diseases, health care providers are more reluctant to embrace detailed phenotyping to guide diagnosis, treatment and prevention in obesity. Given its multiple complex layers, phenotyping necessarily needs to go beyond the multi-omics approach and incorporate all the diverse spheres that conform the reality of people living with obesity. Potential barriers, difficulties, roadblocks and opportunities together with their interaction in a syndemic context are analyzed. Plausible lacunae are also highlighted in addition to pointing to the need of redefining new conceptual frameworks. Therefore, this extraordinary collection of state-ofthe-art reviews provides useful information to both experienced clinicians and trainees as well as academics to steer clinical practice and research in the management of people living with obesity irrespective of practice setting or career stage.

Citing Articles

Increased expression levels of PIEZO1 in visceral adipose tissue in obesity and type 2 diabetes are triggered by mechanical forces and are associated with inflammation.

Catalan V, Gomez-Ambrosi J, Ramirez B, Unamuno X, Becerril S, Rodriguez A Mol Med. 2024; 30(1):255.

PMID: 39707172 PMC: 11660983. DOI: 10.1186/s10020-024-01008-1.

Deep phenotyping obesity using EHR data: Promise, Challenges, and Future Directions.

Ruan X, Lu S, Wang L, Wen A, Sameer M, Liu H medRxiv. 2024; .

PMID: 39677469 PMC: 11643233. DOI: 10.1101/2024.12.06.24318608.

Bacteriophages and their potential for treatment of metabolic diseases.

Deng Y, Jiang S, Duan H, Shao H, Duan Y J Diabetes. 2024; 16(11):e70024.

PMID: 39582431 PMC: 11586638. DOI: 10.1111/1753-0407.70024.

The evolution of the understanding of obesity over the last 100 years.

Gomez-Ambrosi J, Catalan V, Fruhbeck G Int J Obes (Lond). 2024; 49(2):168-176.

PMID: 39506027 DOI: 10.1038/s41366-024-01668-3.

Remission of type 2 diabetes: position statement of the Italian society of diabetes (SID).

Capoccia D, Leonetti F, Natali A, Trico D, Perrini S, Sbraccia P Acta Diabetol. 2024; 61(10):1309-1326.

PMID: 38942960 PMC: 11486812. DOI: 10.1007/s00592-024-02317-x.

References

Cohen R, Petry T . How to address weight regain after bariatric surgery in an individualized way. Rev Endocr Metab Disord. 2023; 24(5):993-1002. DOI: 10.1007/s11154-023-09806-4. View

Fruhbeck G, Busetto L, Dicker D, Yumuk V, Goossens G, Hebebrand J . The ABCD of Obesity: An EASO Position Statement on a Diagnostic Term with Clinical and Scientific Implications. Obes Facts. 2019; 12(2):131-136. PMC: 6547280. DOI: 10.1159/000497124. View

Acosta A, Camilleri M, Shin A, Vazquez-Roque M, Iturrino J, Burton D . Quantitative gastrointestinal and psychological traits associated with obesity and response to weight-loss therapy. Gastroenterology. 2014; 148(3):537-546.e4. PMC: 4339485. DOI: 10.1053/j.gastro.2014.11.020. View

Di Ciaula A, Bonfrate L, Khalil M, Garruti G, Portincasa P . Contribution of the microbiome for better phenotyping of people living with obesity. Rev Endocr Metab Disord. 2023; 24(5):839-870. PMC: 10148591. DOI: 10.1007/s11154-023-09798-1. View

Fruhbeck G, Gomez-Ambrosi J, Salvador J . Leptin-induced lipolysis opposes the tonic inhibition of endogenous adenosine in white adipocytes. FASEB J. 2001; 15(2):333-40. DOI: 10.1096/fj.00-0249com. View

Fruhbeck G, Gomez-Ambrosi J . Modulation of the leptin-induced white adipose tissue lipolysis by nitric oxide. Cell Signal. 2001; 13(11):827-33. DOI: 10.1016/s0898-6568(01)00211-x. View

Fruhbeck G, Gomez-Ambrosi J . Control of body weight: a physiologic and transgenic perspective. Diabetologia. 2003; 46(2):143-72. DOI: 10.1007/s00125-003-1053-4. View

Fruhbeck G, Gomez-Ambrosi J . Rationale for the existence of additional adipostatic hormones. FASEB J. 2001; 15(11):1996-2006. DOI: 10.1096/fj.00-0829hyp. View

Shannon C, Ni Chathail M, Mullin S, Meehan A, McGillicuddy F, Roche H . Precision nutrition for targeting pathophysiology of cardiometabolic phenotypes. Rev Endocr Metab Disord. 2023; 24(5):921-936. PMC: 10492734. DOI: 10.1007/s11154-023-09821-5. View

10.

Blaak E, Goossens G . Metabolic phenotyping in people living with obesity: Implications for dietary prevention. Rev Endocr Metab Disord. 2023; 24(5):825-838. PMC: 10492670. DOI: 10.1007/s11154-023-09830-4. View

11.

Sattar N, McMurray J, McInnes I, Aroda V, Lean M . Treating chronic diseases without tackling excess adiposity promotes multimorbidity. Lancet Diabetes Endocrinol. 2022; 11(1):58-62. DOI: 10.1016/S2213-8587(22)00317-5. View

12.

Preda A, Carbone F, Tirandi A, Montecucco F, Liberale L . Obesity phenotypes and cardiovascular risk: From pathophysiology to clinical management. Rev Endocr Metab Disord. 2023; 24(5):901-919. PMC: 10492705. DOI: 10.1007/s11154-023-09813-5. View

13.

Perdomo C, Cohen R, Sumithran P, Clement K, Fruhbeck G . Contemporary medical, device, and surgical therapies for obesity in adults. Lancet. 2023; 401(10382):1116-1130. DOI: 10.1016/S0140-6736(22)02403-5. View

14.

Catalan V, Gomez-Ambrosi J, Rodriguez A, Perez-Hernandez A, Gurbindo J, Ramirez B . Activation of noncanonical Wnt signaling through WNT5A in visceral adipose tissue of obese subjects is related to inflammation. J Clin Endocrinol Metab. 2014; 99(8):E1407-17. DOI: 10.1210/jc.2014-1191. View

15.

Fruhbeck G, Kiortsis D, Catalan V . Precision medicine: diagnosis and management of obesity. Lancet Diabetes Endocrinol. 2017; 6(3):164-166. DOI: 10.1016/S2213-8587(17)30312-1. View

16.

Camacho-Barcia L, Lucas I, Miranda-Olivos R, Jimenez-Murcia S, Fernandez-Aranda F . Applying psycho-behavioural phenotyping in obesity characterization. Rev Endocr Metab Disord. 2023; 24(5):871-883. PMC: 10492697. DOI: 10.1007/s11154-023-09810-8. View

17.

Aguas-Ayesa M, Yarnoz-Esquiroz P, Olazaran L, Gomez-Ambrosi J, Fruhbeck G . Precision nutrition in the context of bariatric surgery. Rev Endocr Metab Disord. 2023; 24(5):979-991. PMC: 10020075. DOI: 10.1007/s11154-023-09794-5. View

18.

Pulido M, Diaz-Ruiz A, Jimenez-Gomez Y, Garcia-Navarro S, Gracia-Navarro F, Tinahones F . Rab18 dynamics in adipocytes in relation to lipogenesis, lipolysis and obesity. PLoS One. 2011; 6(7):e22931. PMC: 3145781. DOI: 10.1371/journal.pone.0022931. View

19.

Catalan V, Aviles-Olmos I, Rodriguez A, Becerril S, Fernandez-Formoso J, Kiortsis D . Time to Consider the "Exposome Hypothesis" in the Development of the Obesity Pandemic. Nutrients. 2022; 14(8). PMC: 9032727. DOI: 10.3390/nu14081597. View

20.

Fagherazzi G, Zhang L, Aguayo G, Pastore J, Goetzinger C, Fischer A . Towards precision cardiometabolic prevention: results from a machine learning, semi-supervised clustering approach in the nationwide population-based ORISCAV-LUX 2 study. Sci Rep. 2021; 11(1):16056. PMC: 8346462. DOI: 10.1038/s41598-021-95487-5. View