Epigenetic Aging in Cows is Accelerated by Milk Production

Overview

Journal Epigenetics

Specialty Genetics

Date 2023 Aug 3

PMID 37533239

Authors

Prashansa Ratan

Liudmilla Rubbi

Michael Thompson

Kaushik Naresh

Jolena Waddell

Barbara Jones

Matteo Pellegrini

Affiliations

Soon will be listed here.

Abstract

DNA methylation has proven to be the most promising age-predictive biomarker in mammals resulting in the emergence of 'epigenetic clocks' that describe the relationship between methylation levels and age. Using Targeted bisulfite Sequencing, we evaluated blood DNA-methylation data from 96 domesticated cows () of which 88 were adults and 8 were calves. This allowed us to measure DNA methylation across three thousand regions in the genome that were conserved across mammals. The significant association of age with the changes in DNA methylation enabled us to construct an epigenetic clock that predicts the age of cows to within nine months. We also investigated whether factors exist that moderate the association between epigenetic age and actual age and found that milk production levels significantly increase the rate of epigenetic ageing, suggesting that the stress of excessive milk production might be accelerating epigenetic ageing in cows.

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