Diffusion Tensor Imaging of Auditory Pathway: A Comparison of Pediatric Cochlear Implant Candidates and Healthy Cases

Overview

Journal J Int Adv Otol

Publisher Aves

Specialty Otorhinolaryngology

Date 2023 Aug 2

PMID 37528599

Authors

Direnc Ozlem Aksoy

Yesim Karagoz

Kemal Furkan Kaldirimoglu

Melis Baykara Ulusan

Abdullah Soydan Mahmutoglu

Affiliations

Soon will be listed here.

Abstract

Background: We aimed to investigate the changes that may occur in the auditory neural network in pediatric congenital hearing loss cases.

Methods: Fifty-four cochlear implant candidates and 47 normal-hearing controls were included in this retrospective study. Fractional anisotropy, radial diffusivity, and apparent diffusion coefficient maps were generated. We placed region of interest on the cochlear nucleus, superior olivary nucleus, lateral lemniscus, medial geniculate body, auditory radiation, Heschl's gyrus, inferior fronto-occipital fasciculus, superior longitudinal fascicle, and corpus callosum splenium. The area of the cochlear nerve was measured. Diffusion tensor imaging metrics, children's ages, and cochlear nerve area were compared.

Results: Apparent diffusion coefficient and radial diffusivity values of patients were higher than the control group in all places except the radial diffusivity values of medial geniculate body. The fractional anisotropy values of the patients in lateral lemniscus, auditory radiation, Heschl's gyrus, inferior fronto-occipital fasciculus, superior longitudinal fascicle, and corpus callosum splenium were lower than the control group. There is a positive correlation between fractional anisotropy and age in both patient and control groups for all locations. The cochlear nerve area is lower in patients (0.88 ± 0.29) than in the control group (1.18 ± 0.14) (P = .000). The cochlear nerve area has a positive correlation with age in the patient group (P = .000) but has not in the control group. The cochlear nerve area positively correlates with fractional anisotropy values of all locations except fractional anisotropy values of medial geniculate body.

Conclusion: The alterations of diffusion tensor imaging metrics on the auditory pathway reflect the microstructural changes of white matter tracts.

References

Ma W, Li M, Gao F, Zhang X, Shi L, Yu L . DTI Analysis of Presbycusis Using Voxel-Based Analysis. AJNR Am J Neuroradiol. 2016; 37(11):2110-2114. PMC: 7963761. DOI: 10.3174/ajnr.A4870. View

Profant O, Skoch A, Balogova Z, Tintera J, Hlinka J, Syka J . Diffusion tensor imaging and MR morphometry of the central auditory pathway and auditory cortex in aging. Neuroscience. 2013; 260:87-97. DOI: 10.1016/j.neuroscience.2013.12.010. View

Kim S, Kwon H, Kang E, Kim D . Diffusion-Tensor Tractography of the Auditory Neural Pathway : Clinical Usefulness in Patients with Unilateral Sensorineural Hearing Loss. Clin Neuroradiol. 2018; 30(1):115-122. DOI: 10.1007/s00062-018-0733-x. View

Rauschecker J, Tian B . Mechanisms and streams for processing of "what" and "where" in auditory cortex. Proc Natl Acad Sci U S A. 2000; 97(22):11800-6. PMC: 34352. DOI: 10.1073/pnas.97.22.11800. View

Sennaroglu L, Saatci I . A new classification for cochleovestibular malformations. Laryngoscope. 2002; 112(12):2230-41. DOI: 10.1097/00005537-200212000-00019. View

Emmorey K, Allen J, Bruss J, Schenker N, Damasio H . A morphometric analysis of auditory brain regions in congenitally deaf adults. Proc Natl Acad Sci U S A. 2003; 100(17):10049-54. PMC: 187761. DOI: 10.1073/pnas.1730169100. View

Wang H, Liang Y, Fan W, Zhou X, Huang M, Shi G . DTI study on rehabilitation of the congenital deafness auditory pathway and speech center by cochlear implantation. Eur Arch Otorhinolaryngol. 2019; 276(9):2411-2417. PMC: 6682568. DOI: 10.1007/s00405-019-05477-7. View

Rykhlevskaia E, Gratton G, Fabiani M . Combining structural and functional neuroimaging data for studying brain connectivity: a review. Psychophysiology. 2007; 45(2):173-87. DOI: 10.1111/j.1469-8986.2007.00621.x. View

Chang Y, Lee S, Lee Y, Hwang M, Bae S, Kim M . Auditory neural pathway evaluation on sensorineural hearing loss using diffusion tensor imaging. Neuroreport. 2004; 15(11):1699-703. DOI: 10.1097/01.wnr.0000134584.10207.1a. View

10.

Huang L, Zheng W, Wu C, Wei X, Wu X, Wang Y . Diffusion Tensor Imaging of the Auditory Neural Pathway for Clinical Outcome of Cochlear Implantation in Pediatric Congenital Sensorineural Hearing Loss Patients. PLoS One. 2015; 10(10):e0140643. PMC: 4618518. DOI: 10.1371/journal.pone.0140643. View

11.

Zwolan T, Ashbaugh C, Alarfaj A, Kileny P, Arts H, El-Kashlan H . Pediatric cochlear implant patient performance as a function of age at implantation. Otol Neurotol. 2004; 25(2):112-20. DOI: 10.1097/00129492-200403000-00006. View

12.

Dimitriou A, Perisanidis C, Chalkiadakis V, Marangoudakis P, Tzagkaroulakis A, Nikolopoulos T . The universal newborn hearing screening program in a public hospital: The importance of the day of examination. Int J Pediatr Otorhinolaryngol. 2016; 91:90-93. DOI: 10.1016/j.ijporl.2016.10.015. View

13.

Hickok G, Poeppel D . Dorsal and ventral streams: a framework for understanding aspects of the functional anatomy of language. Cognition. 2004; 92(1-2):67-99. DOI: 10.1016/j.cognition.2003.10.011. View

14.

Hoon Park K, Chung W, Kwon H, Lee J . Evaluation of Cerebral White Matter in Prelingually Deaf Children Using Diffusion Tensor Imaging. Biomed Res Int. 2018; 2018:6795397. PMC: 5817214. DOI: 10.1155/2018/6795397. View

15.

Li Y, Ding G, Booth J, Huang R, Lv Y, Zang Y . Sensitive period for white-matter connectivity of superior temporal cortex in deaf people. Hum Brain Mapp. 2011; 33(2):349-59. PMC: 6869854. DOI: 10.1002/hbm.21215. View

16.

Kral A, ODonoghue G . Profound deafness in childhood. N Engl J Med. 2010; 363(15):1438-50. DOI: 10.1056/NEJMra0911225. View

17.

Cunningham L, Tucci D . Hearing Loss in Adults. N Engl J Med. 2017; 377(25):2465-2473. PMC: 6457651. DOI: 10.1056/NEJMra1616601. View

18.

Lin Y, Wang J, Wu C, Wai Y, Yu J, Ng S . Diffusion tensor imaging of the auditory pathway in sensorineural hearing loss: changes in radial diffusivity and diffusion anisotropy. J Magn Reson Imaging. 2008; 28(3):598-603. DOI: 10.1002/jmri.21464. View

19.

Song S, Sun S, Ramsbottom M, Chang C, Russell J, Cross A . Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. Neuroimage. 2002; 17(3):1429-36. DOI: 10.1006/nimg.2002.1267. View

20.

Cope T, Baguley D, Griffiths T . The functional anatomy of central auditory processing. Pract Neurol. 2015; 15(4):302-8. PMC: 4518744. DOI: 10.1136/practneurol-2014-001073. View