Musings on Intrinsic Cardiomyocyte Cell Cycle Activity and Myocardial Regeneration

Overview

Journal J Mol Cell Cardiol

Specialty Cardiology & Vascular Diseases

Date 2023 Jul 30

PMID 37517369

Authors

Mark H Soonpaa

Sean P Reuter

Peter F Castelluccio

Loren J Field

Affiliations

Soon will be listed here.

Abstract

Although the myocardial renewal rate in the adult mammalian heart is quite low, recent studies have identified genetic variants which can impact the degree of cardiomyocyte cell cycle reentry. Here we use the compound interest law to model the level of regenerative growth over time in mice exhibiting different rates of cardiomyocyte cell cycle reentry following myocardial injury. The modeling suggests that the limited ability of S-phase adult cardiomyocytes to progress through cytokinesis, rather than the ability to reenter the cell cycle per se, is a major contributor to the low levels of intrinsic regenerative growth in the adult myocardium.

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