Hyperimmune Globulins for the Management of Infectious Diseases

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2023 Jul 29

PMID 37515229

Authors

Ilaria Pati

Mario Cruciani

Fabio Candura

Maria Simona Massari

Vanessa Piccinini

Francesca Masiello

Samantha Profili

Lucia De Fulvio

Simonetta Pupella

Vincenzo De Angelis

Affiliations

Soon will be listed here.

Abstract

This review is focused on the use of hyperimmune globulin therapy to treat some infectious diseases of viral or bacterial origin. Despite the introduction of antibiotics and vaccines, plasma immunoglobulin therapy from whole blood donation can still play a key role. These treatments provide passive transfer of high-titer antibodies that either reduces the risk or the severity of the infection and offer immediate but short-term protection against specific diseases. Antibody preparations derived from immunized human donors are commonly used for the prophylaxis and treatment of rabies, hepatitis A and B viruses, varicella-zoster virus, and pneumonia caused by respiratory syncytial virus, , . The use of hyperimmune globulin therapy is a promising challenge, especially for the treatment of emerging viral infections for which there are no specific therapies or licensed vaccines.

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