Cetylpyridinium Chloride-Containing Mouthwashes Show Virucidal Activity Against Herpes Simplex Virus Type 1

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2023 Jul 29

PMID 37515121

Authors

Eva Riveira-Munoz

Edurne Garcia-Vidal

Manuel Bano-Polo

Ruben Leon

Vanessa Blanc

Bonaventura Clotet

Ester Ballana

Affiliations

Soon will be listed here.

Abstract

The oral cavity is particularly susceptible to viral infections that are self-recovering in most cases. However, complications may appear in severe cases and/or immunocompromised subjects. Cetylpyridinium chloride (CPC)-containing mouthwashes are able to decrease the infectivity of the SARS-CoV-2 virus by disrupting the integrity of the viral envelope. Here, we show that CPC, as the active ingredient contained in commercialized, exerts significant antiviral activity against enveloped viruses, such as HSV-1, but not against non-enveloped viruses, such as HPV. CPC-containing mouthwashes have been used as antiseptics for decades, and thus, they can represent a cost-effective measure to limit infection and spread of enveloped viruses infecting the oral cavity, aiding in reducing viral transmission.

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