IGF2BP1-An Oncofetal RNA-Binding Protein Fuels Tumor Virus Propagation

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2023 Jul 29

PMID 37515119

Authors

Markus Glass

Stefan Huttelmaier

Affiliations

Soon will be listed here.

Abstract

The oncofetal RNA-binding protein IGF2BP1 has been reported to be a driver of tumor progression in a multitude of cancer entities. Its main function is the stabilization of target transcripts by shielding these from miRNA-mediated degradation. However, there is growing evidence that several virus species recruit IGF2BP1 to promote their propagation. In particular, tumor-promoting viruses, such as hepatitis B/C and human papillomaviruses, benefit from IGF2BP1. Moreover, recent evidence suggests that non-oncogenic viruses, such as SARS-CoV-2, also take advantage of IGF2BP1. The only virus inhibited by IGF2BP1 reported to date is HIV-1. This review summarizes the current knowledge about the interactions between IGF2BP1 and different virus species. It further recapitulates several findings by presenting analyses from publicly available high-throughput datasets.

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