Environmentally Friendly Strategies for Formulating Vegetable Oil-Based Nanoparticles for Anticancer Medicine

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2023 Jul 29

PMID 37514094

Authors

Nathalia Freire

Raquel de Melo Barbosa

Fatima Garcia-Villen

Cesar Viseras

Luana Perioli

Rosana Fialho

Elaine Albuquerque

Affiliations

Soon will be listed here.

Abstract

The development of green synthesized polymeric nanoparticles with anticancer studies has been an emerging field in academia and the pharmaceutical and chemical industries. Vegetable oils are potential substitutes for petroleum derivatives, as they present a clean and environmentally friendly alternative and are available in abundance at relatively low prices. Biomass-derived chemicals can be converted into monomers with a unique structure, generating materials with new properties for the synthesis of sustainable monomers and polymers. The production of bio-based polymeric nanoparticles is a promising application of green chemistry for biomedical uses. There is an increasing demand for biocompatible and biodegradable materials for specific applications in the biomedical area, such as cancer therapy. This is encouraging scientists to work on research toward designing polymers with enhanced properties and clean processes, containing oncology active pharmaceutical ingredients (APIs). The nanoencapsulation of these APIs in bio-based polymeric nanoparticles can control the release of the substances, increase bioavailability, reduce problems of volatility and degradation, reduce side effects, and increase treatment efficiency. This review discusses the use of green chemistry for bio-based nanoparticle production and its application in anticancer medicine. The use of castor oil for the production of renewable monomers and polymers is proposed as an ideal candidate for such applications, as well as more suitable methods for the production of bio-based nanoparticles and some oncology APIs available for anticancer application.

Citing Articles

Biogenic silver nanomaterials synthesized from leaf extract exhibiting robust antimicrobial and anticancer activities: Exploring the therapeutic potential.

Ahmad N, Ansari M, Al-Mahmeed A, Joji R, Saeed N, Shahid M Heliyon. 2024; 10(15):e35486.

PMID: 39170333 PMC: 11336750. DOI: 10.1016/j.heliyon.2024.e35486.

References

Hoyle C, Bowman C . Thiol-ene click chemistry. Angew Chem Int Ed Engl. 2010; 49(9):1540-73. DOI: 10.1002/anie.200903924. View

Zhang Z, Grijpma D, Feijen J . Poly(trimethylene carbonate) and monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate) nanoparticles for the controlled release of dexamethasone. J Control Release. 2006; 111(3):263-70. DOI: 10.1016/j.jconrel.2005.12.001. View

Almajidi Y, Maraie N, Raauf A . Modified solid in oil nanodispersion containing vemurafenib-lipid complex- / study. F1000Res. 2022; 11:841. PMC: 9627402. DOI: 10.12688/f1000research.123041.2. View

Quintanar-Guerrero D, Allemann E, Fessi H, Doelker E . Preparation techniques and mechanisms of formation of biodegradable nanoparticles from preformed polymers. Drug Dev Ind Pharm. 1999; 24(12):1113-28. DOI: 10.3109/03639049809108571. View

Danhier F, Lecouturier N, Vroman B, Jerome C, Marchand-Brynaert J, Feron O . Paclitaxel-loaded PEGylated PLGA-based nanoparticles: in vitro and in vivo evaluation. J Control Release. 2008; 133(1):11-7. DOI: 10.1016/j.jconrel.2008.09.086. View

Di Filippo L, Duarte J, Azambuja J, Mancuso R, Luiz M, Araujo V . Glioblastoma multiforme targeted delivery of docetaxel using bevacizumab-modified nanostructured lipid carriers impair in vitro cell growth and in vivo tumor progression. Int J Pharm. 2022; 618:121682. DOI: 10.1016/j.ijpharm.2022.121682. View

Patel P, Raval M, Manvar A, Airao V, Bhatt V, Shah P . Lung cancer targeting efficiency of Silibinin loaded Poly Caprolactone /Pluronic F68 Inhalable nanoparticles: In vitro and In vivo study. PLoS One. 2022; 17(5):e0267257. PMC: 9106168. DOI: 10.1371/journal.pone.0267257. View

Battaglia L, Gallarate M, Peira E, Chirio D, Solazzi I, Giordano S . Bevacizumab loaded solid lipid nanoparticles prepared by the coacervation technique: preliminary in vitro studies. Nanotechnology. 2015; 26(25):255102. DOI: 10.1088/0957-4484/26/25/255102. View

Wei K, Peng X, Zou F . Folate-decorated PEG-PLGA nanoparticles with silica shells for capecitabine controlled and targeted delivery. Int J Pharm. 2014; 464(1-2):225-33. DOI: 10.1016/j.ijpharm.2013.12.047. View

10.

Schleich N, Sibret P, Danhier P, Ucakar B, Laurent S, Muller R . Dual anticancer drug/superparamagnetic iron oxide-loaded PLGA-based nanoparticles for cancer therapy and magnetic resonance imaging. Int J Pharm. 2013; 447(1-2):94-101. DOI: 10.1016/j.ijpharm.2013.02.042. View

11.

Meier M, Metzger J, Schubert U . Plant oil renewable resources as green alternatives in polymer science. Chem Soc Rev. 2008; 36(11):1788-802. DOI: 10.1039/b703294c. View

12.

Liu X, Jiang J, Chan R, Ji Y, Lu J, Liao Y . Improved Efficacy and Reduced Toxicity Using a Custom-Designed Irinotecan-Delivering Silicasome for Orthotopic Colon Cancer. ACS Nano. 2018; 13(1):38-53. PMC: 6554030. DOI: 10.1021/acsnano.8b06164. View

13.

Biermann U, Bornscheuer U, Meier M, Metzger J, Schafer H . Oils and fats as renewable raw materials in chemistry. Angew Chem Int Ed Engl. 2011; 50(17):3854-71. DOI: 10.1002/anie.201002767. View

14.

Vangara K, Liu J, Palakurthi S . Hyaluronic acid-decorated PLGA-PEG nanoparticles for targeted delivery of SN-38 to ovarian cancer. Anticancer Res. 2013; 33(6):2425-34. View

15.

Cui Y, Xu Q, Chow P, Wang D, Wang C . Transferrin-conjugated magnetic silica PLGA nanoparticles loaded with doxorubicin and paclitaxel for brain glioma treatment. Biomaterials. 2013; 34(33):8511-20. DOI: 10.1016/j.biomaterials.2013.07.075. View

16.

Narayanan S, Mony U, Vijaykumar D, Koyakutty M, Paul-Prasanth B, Menon D . Sequential release of epigallocatechin gallate and paclitaxel from PLGA-casein core/shell nanoparticles sensitizes drug-resistant breast cancer cells. Nanomedicine. 2015; 11(6):1399-406. DOI: 10.1016/j.nano.2015.03.015. View

17.

Wang H, Zhao Y, Wu Y, Hu Y, Nan K, Nie G . Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles. Biomaterials. 2011; 32(32):8281-90. DOI: 10.1016/j.biomaterials.2011.07.032. View

18.

Sousa F, Dhaliwal H, Gattacceca F, Sarmento B, Amiji M . Enhanced anti-angiogenic effects of bevacizumab in glioblastoma treatment upon intranasal administration in polymeric nanoparticles. J Control Release. 2019; 309:37-47. DOI: 10.1016/j.jconrel.2019.07.033. View

19.

Shah M, Naseer M, Choi M, Kim M, Yoon S . Amphiphilic PHA-mPEG copolymeric nanocontainers for drug delivery: preparation, characterization and in vitro evaluation. Int J Pharm. 2010; 400(1-2):165-75. DOI: 10.1016/j.ijpharm.2010.08.008. View

20.

Chen L, Ni X, Zhang H, Wu M, Liu J, Xu S . Preparation, characterization, in vitro and in vivo anti-tumor effect of thalidomide nanoparticles on lung cancer. Int J Nanomedicine. 2018; 13:2463-2476. PMC: 5922239. DOI: 10.2147/IJN.S159327. View