Caffeine for Headaches: Helpful or Harmful? A Brief Review of the Literature
Overview
Affiliations
Consumption of caffeine in the diet, both daily and occasional, has a significant biological effect on the nervous system. Caffeine, through various and not yet fully investigated mechanisms, affects headaches. This is especially noticeable in migraine. In other headaches such as hypnic headache, post-dural puncture headache and spontaneous intracranial hypotension, caffeine is an important therapeutic agent. In turn, abrupt discontinuation of chronically used caffeine can cause caffeine-withdrawal headache. Caffeine can both relieve and trigger headaches.
Quartetti U, Brighina F, Gambino G, Frinchi M, Bellafiore M, Tabacchi G Pain Rep. 2025; 10(2):e1247.
PMID: 39917320 PMC: 11801795. DOI: 10.1097/PR9.0000000000001247.
Genetic susceptibility to caffeine intake and metabolism: a systematic review.
Low J, Tan B, Yi L, Zhou Z, Tan E J Transl Med. 2024; 22(1):961.
PMID: 39438936 PMC: 11515775. DOI: 10.1186/s12967-024-05737-z.
Coffee consumption and migraine: a population-based study.
Cho S, Kim K, Chu M Sci Rep. 2024; 14(1):6007.
PMID: 38472388 PMC: 10933282. DOI: 10.1038/s41598-024-56728-5.
Efficacy of therapies for post dural puncture headache.
Thon J, Weigand M, Kranke P, Siegler B Curr Opin Anaesthesiol. 2024; 37(3):219-226.
PMID: 38372283 PMC: 11062605. DOI: 10.1097/ACO.0000000000001361.