Paclitaxel Delivery to the Brain for Glioblastoma Treatment

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Jul 29

PMID 37511480

Authors

Muhammad Abdel-Haq

Awanish Kumar

Fatima-Ezzahra Ait Mohand

Nataly Kravchenko-Balasha

Yakir Rottenberg

Abraham J Domb

Affiliations

Soon will be listed here.

Abstract

The development of paclitaxel-loaded polymeric nanoparticles for the treatment of brain tumors was investigated. Poly(lactide-glycolide) (PLGA) nanoparticles containing 10% / paclitaxel with a particle size of 216 nm were administered through intranasal and intravenous routes to male Sprague-Dawley rats at a dose of 5 mg/kg. Both routes of administration showed appreciable accumulation of paclitaxel in brain tissue, liver, and kidney without any sign of toxicity. The anti-proliferative effect of the nanoparticles on glioblastoma tumor cells was comparable to that of free paclitaxel.

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