Integrated Analysis of Transcriptome and Metabolome Provides Insight into Oil Alleviating Fat Accumulation in High-Fat

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Jul 29

PMID 37511379

Authors

Li Liu

Qingbo Kong

Zhuoya Xiang

Xuekun Kuang

Heng Wang

Lijun Zhou

Shiling Feng

Tao Chen

Chunbang Ding

Affiliations

Soon will be listed here.

Abstract

Camellia oil (CO) is a high medicinal and nutritional value edible oil. However, its ability to alleviate fat accumulation in high-fat has not been well elucidated. Therefore, this study aimed to investigate the effect of CO on fat accumulation in high-fat via transcriptome and metabolome analysis. The results showed that CO significantly reduced fat accumulation in high-fat by 10.34% (Oil Red O method) and 11.54% (TG content method), respectively. Furthermore, CO primarily altered the transcription levels of genes involved in longevity regulating pathway. Specifically, CO decreased lipid storage in high-fat by inhibiting fat synthesis. In addition, CO supplementation modulated the abundance of metabolic biomarkers related to pyrimidine metabolism and riboflavin metabolism. The integrated transcriptome and metabolome analyses indicated that CO supplementation could alleviate fat accumulation in high-fat by regulating retinol metabolism, drug metabolism-cytochrome P450, metabolism of xenobiotics by cytochrome P450, ascorbate and aldarate metabolism, and pentose and glucuronate interconversions. Overall, these findings highlight the potential health benefits of CO that could potentially be used as a functional edible oil.

Citing Articles

Sweet pepper extract reduces fat storage in by SREBP-SCD axis based on multiomics analysis.

Wang J, Xu P, Liu X, Cao C, Sheng Y, Wang J Food Sci Nutr. 2024; 12(9):6284-6297.

PMID: 39554335 PMC: 11561784. DOI: 10.1002/fsn3.4266.

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