Polyoxometalate K[PMoO] Inactivates O157:H7 by Inducing RecA Expression and Apoptosis-like Bacterial Death

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Jul 29

PMID 37511226

Authors

Shaoling Lin

Zhongjing Lin

Feng Zhou

Dehua Wang

Baodong Zheng

Jiamiao Hu

Affiliations

Soon will be listed here.

Abstract

Polyoxometalates have emerged as promising bactericidal agents. In the current study, the bactericidal activity of polyoxometalate K[PMoO] against () O157:H7 and its possible underlying mechanisms were explored. The obtained results demonstrated that K[PMoO] could effectively kill O157:H7 at millimolar levels. Moreover, K[PMoO] treatment also induced significant increases in recA protein expression and further triggered characteristic apoptosis-like bacterial death events such as DNA fragmentation and phosphatidylserine exposure. In conclusion, polyoxometalate K[PMoO] possesses a desirable antibacterial activity, and induction of bacterial apoptosis-like death might be involved in its underlying bactericidal mechanisms.

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