The Next Frontier in ART: Harnessing the Uterine Immune Profile for Improved Performance

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Jul 29

PMID 37511080

Authors

Nathalie Ledee

Marie Petitbarat

Laura Prat-Ellenberg

Geraldine Dray

Virginie Vaucoret

Alaa Kazhalawi

Andre Rodriguez-Pozo

Nada Habeichi

Lea Ruoso

Nino Guy Cassuto

Mona Rahmati

Affiliations

Soon will be listed here.

Abstract

Assisted reproduction techniques have improved considerably in recent decades, but despite these advances, success rates remain relatively low. Endometrial immune profiling involves the analysis of cytokine biomarkers in the endometrium during the mid-luteal phase. This profiling aims to provide insights into the immune environment of the uterus. The aim is to identify immune disturbances and thus guide the development of personalized therapeutic approaches. The first part of the review looks back at the emergence of innovative concepts, highlighting the specificity of the human uterine environment at the time of implantation. Based on this new knowledge, biomarkers have been selected for endometrial immune profiling. The second part details the results of clinical studies conducted over the last ten years. These clinical results suggest that this approach can increase the rate of live births in patients suffering from repeated implantation failures or repeated pregnancy loss. Uterine immune profiling represents a clinical innovation that can significantly improve the performance of medically assisted reproduction treatments through personalized strategies tailored to the local immune profile. Innovation in personalized medicine for assisted reproduction is crucial to improving the success rates of fertility treatments, while reducing the risks and costs associated with ineffective or unnecessary interventions.

Citing Articles

Endometrial immune profiling and precision therapy increase live birth rate after embryo transfer: a randomised controlled trial.

Ledee N, Petitbarat M, Dray G, Chevrier L, Kazhalawi A, Rahmati M Front Immunol. 2025; 16:1523871.

PMID: 40066441 PMC: 11891216. DOI: 10.3389/fimmu.2025.1523871.

The Interplay of Uterine Health and Obesity: A Comprehensive Review.

Sisljagic D, Blazetic S, Heffer M, Vranjes Delac M, Muller A Biomedicines. 2025; 12(12.

PMID: 39767708 PMC: 11673887. DOI: 10.3390/biomedicines12122801.

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