Glycine: The Smallest Anti-Inflammatory Micronutrient

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Jul 29

PMID 37510995

Authors

Karla Aidee Aguayo-Ceron

Fausto Sanchez-Munoz

Rocio Alejandra Gutierrez-Rojas

Lourdes Nallely Acevedo-Villavicencio

Aurora Vanessa Flores-Zarate

Fengyang Huang

Abraham Giacoman-Martinez

Santiago Villafana

Rodrigo Romero-Nava

Affiliations

Soon will be listed here.

Abstract

Glycine is a non-essential amino acid with many functions and effects. Glycine can bind to specific receptors and transporters that are expressed in many types of cells throughout an organism to exert its effects. There have been many studies focused on the anti-inflammatory effects of glycine, including its abilities to decrease pro-inflammatory cytokines and the concentration of free fatty acids, to improve the insulin response, and to mediate other changes. However, the mechanism through which glycine acts is not clear. In this review, we emphasize that glycine exerts its anti-inflammatory effects throughout the modulation of the expression of nuclear factor kappa B (NF-κB) in many cells. Although glycine is a non-essential amino acid, we highlight how dietary glycine supplementation is important in avoiding the development of chronic inflammation.

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