δ-Opioid Receptor As a Molecular Target for Increasing Cardiac Resistance to Reperfusion in Drug Development

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2023 Jul 29

PMID 37509526

Authors

Natalia V Naryzhnaya

Alexander V Mukhomedzyanov

Maria Sirotina

Leonid N Maslov

Boris K Kurbatov

Alexander S Gorbunov

Mikhail Kilin

Artur Kan

Andrey V Krylatov

Yuri K Podoksenov

Sergey V Logvinov

Affiliations

Soon will be listed here.

Abstract

An analysis of published data and the results of our own studies reveal that the activation of a peripheral δ-opioid receptor (δ-OR) increases the cardiac tolerance to reperfusion. It has been found that this δ-OR is localized in cardiomyocytes. Endogenous opioids are not involved in the regulation of cardiac resistance to reperfusion. The infarct-limiting effect of the δ-OR agonist deltorphin II depends on the activation of several protein kinases, including PKCδ, ERK1/2, PI3K, and PKG. Hypothetical end-effectors of the cardioprotective effect of deltorphin II are the sarcolemmal K channels and the MPT pore.

Citing Articles

Role of β-Adrenergic Receptors in Stress-Induced Cardiac Injury.

Boshchenko A, Kurbatov B, Kilin M, Maslov L, Naryzhnaya N, Saushkin V Bull Exp Biol Med. 2025; 178(3):311-314.

PMID: 39948180 DOI: 10.1007/s10517-025-06327-9.

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