Research Progress on Neurodevelopmental Toxicity in Offspring After Indirect Exposure to PFASs in Early Life

Overview

Journal Toxics

Date 2023 Jul 28

PMID 37505537

Authors

Huai-Yu Zhuchen

Jie-Yu Wang

Xiao-Shan Liu

Yan-Wei Shi

Affiliations

Soon will be listed here.

Abstract

Per- and polyfluoroalkyl substances (PFASs) are widespread environmental pollutants. There is increasing evidence that PFASs have various adverse health effects, including renal toxicity, metabolic dysfunction, endocrine disruption, and developmental toxicity. PFASs have been found to accumulate in the placenta, and some PFASs can cross the placental barrier and subsequently accumulate in the fetus via the maternal-fetal circulation. An increasing number of studies have shown that early life exposure to PFASs can affect fetal neurodevelopment. This paper reviews the characteristics of indirect exposure to PFASs in early life, the effects on neurodevelopment in offspring, and the possible mechanisms of toxic effects.

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