Protocatechuic Acid and Syringin from Nakai Attenuate Prostaglandin Production in Human Keratinocytes Exposed to Airborne Particulate Matter

Overview

Journal Curr Issues Mol Biol

Publisher MDPI

Specialty Molecular Biology

Date 2023 Jul 28

PMID 37504292

Authors

Myeongguk Jeong

Yeongdon Ju

Hyeokjin Kwon

Yeeun Kim

Kyung-Yae Hyun

Go-Eun Choi

Affiliations

Soon will be listed here.

Abstract

Nakai offers a reliable and efficient source of antioxidants that can help alleviate adverse skin reactions triggered by air pollutants. Air pollutants, such as particulate matter (PM), have the ability to infiltrate the skin and contribute to the higher occurrence of cardiovascular, cerebrovascular, and respiratory ailments. Individuals with compromised skin barriers are particularly susceptible to the impact of PM since it can be absorbed more readily through the skin. This study investigated the impact of protocatechuic acid and syringin, obtained from the n-BuOH extract of Nakai, on the release of PGE and PGD induced by PM. Additionally, it examined the gene expression of the synthesis of PGE and PGD in human keratinocytes. The findings of this research highlight the potential of utilizing safe and efficient plant-derived antioxidants in dermatological and cosmetic applications to mitigate the negative skin reactions caused by exposure to air pollution.

Citing Articles

Extract Improves DNCB-Induced Atopic Dermatitis in a Mouse Model via the Nrf2/HO-1 Pathway.

Jeong M, Kwon H, Kim Y, Jin H, Choi G, Hyun K Nutrients. 2024; 16(3).

PMID: 38337735 PMC: 10857527. DOI: 10.3390/nu16030451.

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