S1P/S1PR Signaling Pathway Advancements in Autoimmune Diseases

Overview

Journal Biomol Biomed

Specialties Biochemistry
General Medicine

Date 2023 Jul 28

PMID 37504219

Authors

Jianbin Li

Yiping Huang

Yueqin Zhang

Pengcheng Liu

Mengxia Liu

Min Zhang

Rui Wu

Affiliations

Soon will be listed here.

Abstract

Sphingosine-1-phosphate (S1P) is a versatile sphingolipid that is generated through the phosphorylation of sphingosine by sphingosine kinase (SPHK). S1P exerts its functional effects by binding to the G protein-coupled S1P receptor (S1PR). This lipid mediator plays a pivotal role in various cellular activities. The S1P/S1PR signaling pathway is implicated in the pathogenesis of immune-mediated diseases, significantly contributing to the functioning of the immune system. It plays a crucial role in diverse physiological and pathophysiological processes, including cell survival, proliferation, migration, immune cell recruitment, synthesis of inflammatory mediators, and the formation of lymphatic and blood vessels. However, the full extent of the involvement of this signaling pathway in the development of autoimmune diseases remains to be fully elucidated. Therefore, this study aims to comprehensively review recent research on the S1P/S1PR axis in diseases related to autoimmunity.

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