» Articles » PMID: 37502185

Case Report: New is Not Always Better: Treatment of Non-bacterial Thrombotic Endocarditis

Overview
Authors
Affiliations
Soon will be listed here.
Abstract

An elderly female with metastatic adenocarcinoma of the lung and atrial fibrillation presented with multiple embolic strokes while on anticoagulation with Apixaban. After further investigation, a TEE showed lesions of non-bacterial thrombotic endocarditis on the mitral valve. A decision to switch the patient to LMWH for anticoagulation was then made and a follow-up TEE showed resolution of the NBTE. In this abstract, we show that heparin should remain as the anticoagulation agent of choice in the setting of NBTE associated with malignancy.

Citing Articles

Perioperative Management of a Case of Trousseau Syndrome Accompanied by Aortic Valve Vegetation.

Harada M, Ochiai Y, Sawamura S Cureus. 2025; 17(1):e77202.

PMID: 39931596 PMC: 11808285. DOI: 10.7759/cureus.77202.


Exploring the Complexities of Non-Bacterial Thrombotic Endocarditis: Highlights from Literature and Case Studies.

Santarpino G, Lofrumento F, Zito C, Trio O, Restelli D, Piccione M J Clin Med. 2024; 13(16).

PMID: 39201046 PMC: 11355671. DOI: 10.3390/jcm13164904.


Non-bacterial thrombotic endocarditis in a patient with COVID.

Ahmad A, Golemi L, Bedi R, Sanfilippo K, Poowanawittayakom N, Ou J BMJ Case Rep. 2023; 16(10).

PMID: 37865419 PMC: 10603479. DOI: 10.1136/bcr-2023-256264.

References
1.
Rogers L, Cho E, Kempin S, Posner J . Cerebral infarction from non-bacterial thrombotic endocarditis. Clinical and pathological study including the effects of anticoagulation. Am J Med. 1987; 83(4):746-56. DOI: 10.1016/0002-9343(87)90908-9. View

2.
Li A, Garcia D, Lyman G, Carrier M . Direct oral anticoagulant (DOAC) versus low-molecular-weight heparin (LMWH) for treatment of cancer associated thrombosis (CAT): A systematic review and meta-analysis. Thromb Res. 2018; 173:158-163. PMC: 6119655. DOI: 10.1016/j.thromres.2018.02.144. View

3.
Shoji M, Kim J, Bakshi S, Govea N, Marukian N, Wang S . Nonbacterial Thrombotic Endocarditis Due to Primary Gallbladder Malignancy with Recurrent Stroke Despite Anticoagulation: Case Report and Literature Review. J Gen Intern Med. 2019; 34(9):1934-1940. PMC: 6712189. DOI: 10.1007/s11606-019-05166-5. View

4.
Mantovani F, Navazio A, Barbieri A, Boriani G . A first described case of cancer-associated non-bacterial thrombotic endocarditis in the era of direct oral anticoagulants. Thromb Res. 2016; 149:45-47. DOI: 10.1016/j.thromres.2016.11.016. View

5.
Al Chalaby S, Makhija R, Sharma A, Majid M, Aman E, Venugopal S . Nonbacterial Thrombotic Endocarditis: Presentation, Pathophysiology, Diagnosis and Management. Rev Cardiovasc Med. 2024; 23(4):137. PMC: 11273749. DOI: 10.31083/j.rcm2304137. View