The Human Microbiome and Cancer: a Diagnostic and Therapeutic Perspective

Overview

Journal Cancer Biol Ther

Specialties Oncology
Pharmacology

Date 2023 Jul 27

PMID 37498047

Authors

Shruthi Kandalai

Huapeng Li

Nan Zhang

Haidong Peng

Qingfei Zheng

Affiliations

Soon will be listed here.

Abstract

Recent evidence has shown that the human microbiome is associated with various diseases, including cancer. The salivary microbiome, fecal microbiome, and circulating microbial DNA in blood plasma have all been used experimentally as diagnostic biomarkers for many types of cancer. The microbiomes present within local tissue, other regions, and tumors themselves have been shown to promote and restrict the development and progression of cancer, most often by affecting cancer cells or the host immune system. These microbes have also been shown to impact the efficacy of various cancer therapies, including radiation, chemotherapy, and immunotherapy. Here, we review the research advances focused on how microbes impact these different facets and why they are important to the clinical care of cancer. It is only by better understanding the roles these microbes play in the diagnosis, development, progression, and treatment of cancer, that we will be able to catch and treat cancer early.

Citing Articles

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