Combination Therapy of Antibiotics and Platelet-rich Fibrin for Apical Closure: Case Series

Overview

Journal Int J Clin Pediatr Dent

Specialty Pediatrics

Date 2023 Jul 27

PMID 37496947

Authors

Nandini Biradar

Rajesh Ragulakollu

Gururam Tej

Chittaranjan Bogishetty

Srehitha Gandham

Pavan Vardhan

Affiliations

Soon will be listed here.

Abstract

Case Description: An 11-year-old girl, a 9-year-old boy, and a 13-year-old boy, symptomatic patients with open apex, are treated with TAP, PRF, and mineral trioxide aggregate (MTA) as an apical barrier sequentially. There was the formation of a calcific barrier at the end of 12, 6, and 3 months, respectively.

Conclusion: Correct diagnosis and protocol of sequential disinfection, regeneration, and finally filling the canal with an apical barrier could yield better results.

How To Cite This Article: Biradar N, Ragulakollu R, Tej G, Combination Therapy of Antibiotics and Platelet-rich Fibrin for Apical Closure: Case Series. Int J Clin Pediatr Dent 2023;16(3):541-546.

References

Bystrom A, Sundqvist G . Bacteriologic evaluation of the efficacy of mechanical root canal instrumentation in endodontic therapy. Scand J Dent Res. 1981; 89(4):321-8. DOI: 10.1111/j.1600-0722.1981.tb01689.x. View

Yadav P, Pruthi P, Naval R, Talwar S, Verma M . Novel use of platelet-rich fibrin matrix and MTA as an apical barrier in the management of a failed revascularization case. Dent Traumatol. 2015; 31(4):328-31. DOI: 10.1111/edt.12168. View

Patil R, Kumar B, Lee W, Jeon R, Jang S, Lee Y . Multilineage potential and proteomic profiling of human dental stem cells derived from a single donor. Exp Cell Res. 2013; 320(1):92-107. DOI: 10.1016/j.yexcr.2013.10.005. View

McCormick J, Weine F, Maggio J . Tissue pH of developing periapical lesions in dogs. J Endod. 1983; 9(2):47-51. DOI: 10.1016/S0099-2399(83)80074-0. View

Matt G, Thorpe J, Strother J, McClanahan S . Comparative study of white and gray mineral trioxide aggregate (MTA) simulating a one- or two-step apical barrier technique. J Endod. 2004; 30(12):876-9. DOI: 10.1097/01.don.0000136213.93171.45. View

Ragab R, Lattif A, Dokky N . Comparative Study between Revitalization of Necrotic Immature Permanent Anterior Teeth with and without Platelet Rich Fibrin: A Randomized Controlled Trial. J Clin Pediatr Dent. 2019; 43(2):78-85. DOI: 10.17796/1053-4625-43.2.2. View

Karan N, Aricioglu B . Assessment of bone healing after mineral trioxide aggregate and platelet-rich fibrin application in periapical lesions using cone-beam computed tomographic imaging. Clin Oral Investig. 2019; 24(2):1065-1072. DOI: 10.1007/s00784-019-03003-x. View

Gougousis K, Giannakoulas D, Taraslia V, Agrafioti A, Anastasiadou E, Kontakiotis E . Number of Dental Stem Cells on Root Canal Dentin after Application of Triple Antibiotic Paste or Calcium Hydroxide: An In Vitro Study. Eur J Dent. 2019; 13(2):161-165. PMC: 6777155. DOI: 10.1055/s-0039-1688733. View

Jadhav G, Shah N, Logani A . Revascularization with and without platelet-rich plasma in nonvital, immature, anterior teeth: a pilot clinical study. J Endod. 2012; 38(12):1581-7. DOI: 10.1016/j.joen.2012.09.010. View

10.

Narang I, Mittal N, Mishra N . A comparative evaluation of the blood clot, platelet-rich plasma, and platelet-rich fibrin in regeneration of necrotic immature permanent teeth: A clinical study. Contemp Clin Dent. 2015; 6(1):63-8. PMC: 4319348. DOI: 10.4103/0976-237X.149294. View

11.

Iwaya S, Ikawa M, Kubota M . Revascularization of an immature permanent tooth with apical periodontitis and sinus tract. Dent Traumatol. 2001; 17(4):185-7. DOI: 10.1034/j.1600-9657.2001.017004185.x. View

12.

Bi J, Liu Y, Liu X, Lei S, Chen X . Platelet-rich Fibrin Improves the Osteo-/Odontogenic Differentiation of Stem Cells from Apical Papilla via the Extracellular Signal-regulated Protein Kinase Signaling Pathway. J Endod. 2020; 46(5):648-654. DOI: 10.1016/j.joen.2020.02.004. View

13.

Banchs F, Trope M . Revascularization of immature permanent teeth with apical periodontitis: new treatment protocol?. J Endod. 2004; 30(4):196-200. DOI: 10.1097/00004770-200404000-00003. View

14.

Morse D, OLarnic J, Yesilsoy C . Apexification: review of the literature. Quintessence Int. 1990; 21(7):589-98. View

15.

Adl A, Hamedi S, Sedigh Shams M, Motamedifar M, Sobhnamayan F . The ability of triple antibiotic paste and calcium hydroxide in disinfection of dentinal tubules. Iran Endod J. 2014; 9(2):123-6. PMC: 3961590. View

16.

Sonoyama W, Liu Y, Yamaza T, Tuan R, Wang S, Shi S . Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study. J Endod. 2008; 34(2):166-71. PMC: 2714367. DOI: 10.1016/j.joen.2007.11.021. View

17.

Bansal R, Jain A . Overview on the current antibiotic containing agents used in endodontics. N Am J Med Sci. 2014; 6(8):351-8. PMC: 4158642. DOI: 10.4103/1947-2714.139277. View

18.

Petrino J, Boda K, Shambarger S, Bowles W, McClanahan S . Challenges in regenerative endodontics: a case series. J Endod. 2010; 36(3):536-41. DOI: 10.1016/j.joen.2009.10.006. View

19.

Huang F, Yang S, Zhao J, Chang Y . Platelet-rich fibrin increases proliferation and differentiation of human dental pulp cells. J Endod. 2010; 36(10):1628-32. DOI: 10.1016/j.joen.2010.07.004. View

20.

Mohammadi Z, Jafarzadeh H, Shalavi S, Yaripour S, Sharifi F, Kinoshita J . A Review on Triple Antibiotic Paste as a Suitable Material Used in Regenerative Endodontics. Iran Endod J. 2018; 13(1):1-6. PMC: 5800433. DOI: 10.22037/iej.v13i1.17941. View