The Sodium Does Not Affect Joint Pain and Functional Activity of Knee Osteoarthritis Patients

Overview

Journal J Public Health Afr

Date 2023 Jul 26

PMID 37492557

Authors

Anisyah Achmad

Suharjono

Joewono Soeroso

Budi Suprapti

Siswandono

Liza Pristianty

Mahardian Rahmadi

Jusak Nugraha

Cahyo Wibisono Nugroho

Yoki Surya

Satria Pandu Persada Isma

Erreza Rahadiansyah

Thomas Erwin C J Huwae

Bagus Putu Putra Suryana

Affiliations

Soon will be listed here.

Abstract

Background: The sodium may aggravate synovial inflammation and cartilage thinning. This incidence can cause joint pain and reduce functional activity. Not many people know the effect of sodium on the incidence of osteoarthritis.

Objective: This study aims to determine the relationship between sodium in the body and knee joint pain which results in functional activity.

Methods: The quantitative descriptive study used accidental sampling. The study was conducted at three outpatient polyclinic orthopedics of hospitals and was approved by the Health Ethics Committee. All data were collected during the interview. The Semi-Quantitative Food Frequency Questionnaire and the Nutrisurvey Indonesia 2007 application were used as a tool to collect daily sodium intake (mg). Knee joint pain score was measured using the Visual Analog Scale (VAS), while functional body activity was measured using the Western Ontario McMaster Osteoarthritis Index (WOMAC). The Pearson and Spearman test (P<0.05) were used as a correlation test.

Results: 80 subjects were recruited according to the inclusion criteria. Characteristics of the subjects were pre-elderly (32, 40%), women (74, 92.5%), body mass index ≥30 kg/m (54, 67.5%) and occupation (43, 53.75%). Average sodium intake = 2090.78±1084.33 mg, VAS score = 6.28±1.95 and WOMAC score = 32.65±14.88. The correlation sodium, VAS, and WOMAC were not significant (P=0.196, P=0.372).

Conclusions: Increased sodium intake is not associated with knee joint pain and functional body activity.

References

Dar H, Singh A, Shukla P, Anupam R, Mondal R, Mishra P . High dietary salt intake correlates with modulated Th17-Treg cell balance resulting in enhanced bone loss and impaired bone-microarchitecture in male mice. Sci Rep. 2018; 8(1):2503. PMC: 5802842. DOI: 10.1038/s41598-018-20896-y. View

Bennell K, Nelligan R, Kimp A, Wrigley T, Metcalf B, Kasza J . Comparison of weight bearing functional exercise and non-weight bearing quadriceps strengthening exercise on pain and function for people with knee osteoarthritis and obesity: protocol for the TARGET randomised controlled trial. BMC Musculoskelet Disord. 2019; 20(1):291. PMC: 6580522. DOI: 10.1186/s12891-019-2662-5. View

Dobson G, Letson H, Grant A, McEwen P, Hazratwala K, WILKINSON M . Defining the osteoarthritis patient: back to the future. Osteoarthritis Cartilage. 2018; 26(8):1003-1007. DOI: 10.1016/j.joca.2018.04.018. View

Koshy P, Henderson N, Logan C, Life P, Cawston T, Rowan A . Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines. Ann Rheum Dis. 2002; 61(8):704-13. PMC: 1754191. DOI: 10.1136/ard.61.8.704. View

Wu C, Yosef N, Thalhamer T, Zhu C, Xiao S, Kishi Y . Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature. 2013; 496(7446):513-7. PMC: 3637879. DOI: 10.1038/nature11984. View

Tang J, Liu T, Wen X, Zhou Z, Yan J, Gao J . Estrogen-related receptors: novel potential regulators of osteoarthritis pathogenesis. Mol Med. 2021; 27(1):5. PMC: 7809777. DOI: 10.1186/s10020-021-00270-x. View

Braveman P, Egerter S, Williams D . The social determinants of health: coming of age. Annu Rev Public Health. 2010; 32:381-98. DOI: 10.1146/annurev-publhealth-031210-101218. View

Stewart H, Kawcak C . The Importance of Subchondral Bone in the Pathophysiology of Osteoarthritis. Front Vet Sci. 2018; 5:178. PMC: 6122109. DOI: 10.3389/fvets.2018.00178. View

Chen B, Deng Y, Tan Y, Qin J, Chen L . Association between severity of knee osteoarthritis and serum and synovial fluid interleukin 17 concentrations. J Int Med Res. 2013; 42(1):138-44. DOI: 10.1177/0300060513501751. View

10.

Xu X, Li X, Liang Y, Ou Y, Huang J, Xiong J . Estrogen Modulates Cartilage and Subchondral Bone Remodeling in an Ovariectomized Rat Model of Postmenopausal Osteoarthritis. Med Sci Monit. 2019; 25:3146-3153. PMC: 6503753. DOI: 10.12659/MSM.916254. View

11.

Kolasinski S, Neogi T, Hochberg M, Oatis C, Guyatt G, Block J . 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Arthritis Rheumatol. 2020; 72(2):220-233. PMC: 10518852. DOI: 10.1002/art.41142. View

12.

Naugle K, Naugle K, Riley 3rd J . Reduced Modulation of Pain in Older Adults After Isometric and Aerobic Exercise. J Pain. 2016; 17(6):719-28. PMC: 5006180. DOI: 10.1016/j.jpain.2016.02.013. View

13.

Felson D . Risk factors for osteoarthritis: understanding joint vulnerability. Clin Orthop Relat Res. 2004; (427 Suppl):S16-21. DOI: 10.1097/01.blo.0000144971.12731.a2. View

14.

Brown I, Tzoulaki I, Candeias V, Elliott P . Salt intakes around the world: implications for public health. Int J Epidemiol. 2009; 38(3):791-813. DOI: 10.1093/ije/dyp139. View

15.

Jiang L, Zhou X, Xiong Y, Bao J, Xu K, Wu L . Association between interleukin-17A/F single nucleotide polymorphisms and susceptibility to osteoarthritis in a Chinese population. Medicine (Baltimore). 2019; 98(12):e14944. PMC: 6708862. DOI: 10.1097/MD.0000000000014944. View

16.

Appel L, Frohlich E, Hall J, Pearson T, Sacco R, Seals D . The importance of population-wide sodium reduction as a means to prevent cardiovascular disease and stroke: a call to action from the American Heart Association. Circulation. 2011; 123(10):1138-43. DOI: 10.1161/CIR.0b013e31820d0793. View

17.

McGuire S . Institute of Medicine. 2010. Strategies to Reduce Sodium Intake in the United States. Washington, DC: The National Academies Press. Adv Nutr. 2011; 1(1):49-50. PMC: 3042781. DOI: 10.3945/an.110.1002. View

18.

Sinkeviciute D, Aspberg A, He Y, Bay-Jensen A, Onnerfjord P . Characterization of the interleukin-17 effect on articular cartilage in a translational model: an explorative study. BMC Rheumatol. 2020; 4:30. PMC: 7216541. DOI: 10.1186/s41927-020-00122-x. View

19.

Febbraio M, Pedersen B . Contraction-induced myokine production and release: is skeletal muscle an endocrine organ?. Exerc Sport Sci Rev. 2005; 33(3):114-9. DOI: 10.1097/00003677-200507000-00003. View

20.

Le Goff B, Bouvard B, Lequerre T, Lespessailles E, Marotte H, Pers Y . Implication of IL-17 in Bone Loss and Structural Damage in Inflammatory Rheumatic Diseases. Mediators Inflamm. 2019; 2019:8659302. PMC: 6710740. DOI: 10.1155/2019/8659302. View