Long-term Outcomes of Single and Dual En Bloc Kidney Transplants From Small Pediatric Donors: An ANZDATA Registry Study

Overview

Journal Transplant Direct

Publisher Wolters Kluwer

Specialty General Surgery

Date 2023 Jul 26

PMID 37492077

Authors

Jacques G Eastment

Elizabeth G Ryan

Scott Campbell

Mark Ray

Andrea K Viecelli

Dev Jegatheesan

Vijay Kanagarajah

Anthony Griffin

John M Preston

David W Johnson

Nicole Isbel

Affiliations

Soon will be listed here.

Abstract

Methods: Data were obtained from the Australia and New Zealand Dialysis and Transplant Registry. All adult recipients of kidney transplants from donors aged ≤5 y were identified. The primary outcome of interest was death-censored graft survival by donor type. The secondary outcomes were early graft loss, delayed graft function, serum creatinine posttransplantation, acute rejection, and patient survival.

Results: There were 183 adult recipients of kidney transplants from donors aged ≤5 y old. Of these, 60 patients had EBKT grafts, 79 patients had SKT grafts, and 44 patients had grafts of unknown type. Compared with SKT donors, EBKT donors had lower mean age ( < 0.001) and body weight ( < 0.001). There was no significant difference in death-censored graft survival between the groups, with median survival of 23.8 y (interquartile range 21.2-25) in the EBKT cohort and 21.8 y (11.6-26.8) in the SKT cohort (hazard ratio 1.3; 95% confidence interval, 0.59-2.64; = 0.56). EBKT grafts had lower acute rejection rates than SKT grafts ( = 0.014). There was no significant difference observed between groups with respect to early graft loss, delayed graft function, posttransplantation serum creatinine posttransplantation, or patient survival.

Conclusions: EBKT and SKTs from small pediatric donors are associated with excellent long-term graft survival rates.

Citing Articles

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