Development, Circuitry, and Function of the Zebrafish Cerebellum

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2023 Jul 25

PMID 37490159

Authors

Sol Pose-Mendez

Paul Schramm

Komali Valishetti

Reinhard W Koster

Affiliations

Soon will be listed here.

Abstract

The cerebellum represents a brain compartment that first appeared in gnathostomes (jawed vertebrates). Besides the addition of cell numbers, its development, cytoarchitecture, circuitry, physiology, and function have been highly conserved throughout avian and mammalian species. While cerebellar research in avian and mammals is extensive, systematic investigations on this brain compartment in zebrafish as a teleostian model organism started only about two decades ago, but has provided considerable insight into cerebellar development, physiology, and function since then. Zebrafish are genetically tractable with nearly transparent small-sized embryos, in which cerebellar development occurs within a few days. Therefore, genetic investigations accompanied with non-invasive high-resolution in vivo time-lapse imaging represents a powerful combination for interrogating the behavior and function of cerebellar cells in their complex native environment.

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