Finding the Priority and Cluster of Inflammatory Biomarkers for Infectious Preterm Birth: a Systematic Review

Overview

Journal J Inflamm (Lond)

Publisher Biomed Central

Date 2023 Jul 24

PMID 37488605

Authors

Jiayi Li

Jianrong Ge

Na Ran

Changwu Zheng

Yumeng Fang

Danna Fang

Qian Yang

Yeling Ma

Affiliations

Soon will be listed here.

Abstract

Infectious preterm birth (PTB) is one of the most important causes of perinatal death. It is difficult to find reliable biomarkers accurate to gestational weeks for infectious PTB prediction clinically. Infectious PTB is found usually accompanied with immune imbalance. Thus, the systematic study to find the priority of inflammatory biomarkers and innovative inflammatory clusters for infectious PTB prediction is urgently needed.This systematic study that focused on the inflammatory clusters and infectious PTB in the PubMed database was analyzed by using the criteria of the Population, Intervention, Comparison, Outcome, and Study design (PICOS) framework according to the recommendations of preferred reporting items for systematic reviews and meta-analysis (PRISMA).The network meta-analyzed results showed that the prioritization of the inflammatory factors for infectious PTB prediction is soluble tumor necrosis factor receptor 2 (sTNFR2) > tumor necrosis factor α (TNFα) > interleukin-10 (IL-10) > interleukin-6 (IL-6) > C-reactive protein (CRP) > interleukin-1β (IL-1β). Furthermore, the results also indicated that global consideration of multiple inflammatory factors, such as CRP/IL-1β/IL-6 biomarker cluster in gestational 27-34 weeks, and the tumor necrosis factor/nerve growth factor (TNF/NGF) family during gestational 25-33 weeks, were potential biomarker clusters that specific for infectious PTB prediction.This study systematically pointed out prioritization of the inflammatory factors for infectious PTB prediction. The results also provided evidence that maternal inflammatory clusters can predict infectious PTB occurrence at accurate gestational week. The global consideration of multiple inflammatory factors at accurate gestational age is highlighted.

References

Erlebacher A . Immunology of the maternal-fetal interface. Annu Rev Immunol. 2013; 31:387-411. DOI: 10.1146/annurev-immunol-032712-100003. View

Romero R, Gomez R, Chaiworapongsa T, Conoscenti G, Kim J, Kim Y . The role of infection in preterm labour and delivery. Paediatr Perinat Epidemiol. 2001; 15 Suppl 2:41-56. DOI: 10.1046/j.1365-3016.2001.00007.x. View

Moutsopoulos N, Madianos P . Low-grade inflammation in chronic infectious diseases: paradigm of periodontal infections. Ann N Y Acad Sci. 2006; 1088:251-64. DOI: 10.1196/annals.1366.032. View

Elovitz M, Wang Z, Chien E, Rychlik D, Phillippe M . A new model for inflammation-induced preterm birth: the role of platelet-activating factor and Toll-like receptor-4. Am J Pathol. 2003; 163(5):2103-11. PMC: 1892431. DOI: 10.1016/S0002-9440(10)63567-5. View

Garcia-Ruiz G, Flores-Espinosa P, Preciado-Martinez E, Bermejo-Martinez L, Espejel-Nunez A, Estrada-Gutierrez G . In vitro progesterone modulation on bacterial endotoxin-induced production of IL-1β, TNFα, IL-6, IL-8, IL-10, MIP-1α, and MMP-9 in pre-labor human term placenta. Reprod Biol Endocrinol. 2015; 13:115. PMC: 4596542. DOI: 10.1186/s12958-015-0111-3. View

Saito S, Nishikawa K, Morii T, Enomoto M, Narita N, Motoyoshi K . Cytokine production by CD16-CD56bright natural killer cells in the human early pregnancy decidua. Int Immunol. 1993; 5(5):559-63. DOI: 10.1093/intimm/5.5.559. View

Christiaens I, Zaragoza D, Guilbert L, Robertson S, Mitchell B, Olson D . Inflammatory processes in preterm and term parturition. J Reprod Immunol. 2008; 79(1):50-7. DOI: 10.1016/j.jri.2008.04.002. View

Skrablin S, Lovric H, Banovic V, Kralik S, Dijakovic A, Kalafatic D . Maternal plasma interleukin-6, interleukin-1beta and C-reactive protein as indicators of tocolysis failure and neonatal outcome after preterm delivery. J Matern Fetal Neonatal Med. 2007; 20(4):335-41. DOI: 10.1080/14767050701227877. View

Pandey M, Chauhan M, Awasthi S . Interplay of cytokines in preterm birth. Indian J Med Res. 2018; 146(3):316-327. PMC: 5793465. DOI: 10.4103/ijmr.IJMR_1624_14. View

10.

Romero R, Mazor M, Brandt F, Sepulveda W, Avila C, Cotton D . Interleukin-1 alpha and interleukin-1 beta in preterm and term human parturition. Am J Reprod Immunol. 1992; 27(3-4):117-23. DOI: 10.1111/j.1600-0897.1992.tb00737.x. View

11.

Escobar-Arregoces F, Latorre-Uriza C, Velosa-Porras J, Roa-Molina N, Ruiz A, Silva J . Inflamatory response in pregnant women with high risk of preterm delivery and its relationship with periodontal disease: a pilot study. Acta Odontol Latinoam. 2018; 31(1):53-57. View

12.

Martin J, Hamilton B, Osterman M, Driscoll A, Mathews T . Births: Final Data for 2015. Natl Vital Stat Rep. 2017; 66(1):1. View

13.

Hirsch E, Saotome I, Hirsh D . A model of intrauterine infection and preterm delivery in mice. Am J Obstet Gynecol. 1995; 172(5):1598-603. DOI: 10.1016/0002-9378(95)90503-0. View

14.

Romero R, Dey S, Fisher S . Preterm labor: one syndrome, many causes. Science. 2014; 345(6198):760-5. PMC: 4191866. DOI: 10.1126/science.1251816. View

15.

Erlandson K, Wilson M, MaWhinney S, Rapaport E, Liu J, Wilson C . The Impact of Moderate or High-Intensity Combined Exercise on Systemic Inflammation Among Older Persons With and Without HIV. J Infect Dis. 2020; 223(7):1161-1170. PMC: 8030723. DOI: 10.1093/infdis/jiaa494. View

16.

Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M . Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ. 2015; 350:g7647. DOI: 10.1136/bmj.g7647. View

17.

Chawanpaiboon S, Vogel J, Moller A, Lumbiganon P, Petzold M, Hogan D . Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis. Lancet Glob Health. 2018; 7(1):e37-e46. PMC: 6293055. DOI: 10.1016/S2214-109X(18)30451-0. View

18.

Gupta J, Care A, Goodfellow L, Alfirevic Z, Muller-Myhsok B, Alfirevic A . Publisher Correction: Genome and transcriptome profiling of spontaneous preterm birth phenotypes. Sci Rep. 2022; 12(1):1986. PMC: 8807601. DOI: 10.1038/s41598-022-06338-w. View

19.

Yang F, Zheng Q, Jin L . Dynamic Function and Composition Changes of Immune Cells During Normal and Pathological Pregnancy at the Maternal-Fetal Interface. Front Immunol. 2019; 10:2317. PMC: 6813251. DOI: 10.3389/fimmu.2019.02317. View

20.

Villar-Fincheira P, Sanhueza-Olivares F, Norambuena-Soto I, Cancino-Arenas N, Hernandez-Vargas F, Troncoso R . Role of Interleukin-6 in Vascular Health and Disease. Front Mol Biosci. 2021; 8:641734. PMC: 8004548. DOI: 10.3389/fmolb.2021.641734. View