The Genome of Antibiotic-producing Colonies of the Pelagophyte Alga Chrysophaeum Taylorii Reveals a Diverse and Non-canonical Capacity for Secondary Metabolism

Overview

Journal Sci Rep

Specialty Science

Date 2023 Jul 24

PMID 37488207

Authors

Jack R Davison

Rahim Rajwani

Gengxiang Zhao

Carole A Bewley

Affiliations

Soon will be listed here.

Abstract

Chrysophaeum taylorii is a member of an understudied clade of marine algae that can be responsible for harmful coastal blooms and is known to accumulate bioactive natural products including antibiotics of the chrysophaentin class. Whole genome sequencing of laboratory-cultivated samples revealed an extensive and diverse complement of secondary metabolite biosynthetic genes in C. taylorii, alongside a small microbiome with a more limited biosynthetic potential. 16S microbiome analysis of laboratory cultured alongside wild-collected samples revealed several common taxa; however, analysis of biosynthetic genes suggested an algal origin for the chrysophaentins, possibly via one of several non-canonical polyketide synthase genes encoded within the genome.

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