Case Report: A Case of Bone Marrow Necrosis and Hyperinflammation in a 10-Year-Old Boy After Plasmodium Falciparum Infection

Overview

Journal Am J Trop Med Hyg

Specialty Tropical Medicine

Date 2023 Jul 24

PMID 37487563

Authors

Caitlyn Hui

Alessandra Bosch

Oscar Mwizerwa

Jeanine McColl

Antoine Corbeil

Caroline Malcolmson

Deborah M Levy

Zia Bismilla

Shaun K Morris

Affiliations

Soon will be listed here.

Abstract

A 10-year-old boy with sickle cell disease (SCD) type SC presented with fever and abdominal pain after travel to Ghana and was diagnosed with Plasmodium falciparum infection. Despite adequate antimalarial treatment, he developed evidence of hyperinflammation with marked elevated ferritin, C-reactive protein, and triglycerides and subsequent bone marrow necrosis, characterized by elevated nucleated red blood cells and significant bone pain. This case report highlights the possible association between malaria and bone marrow necrosis in patients with SCD. Important considerations in treatment and workup of patients presenting with malaria and hyperinflammation are discussed.

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