Role of Peptidylarginine Deiminase 4 in Central Nervous System Diseases

Overview

Journal Mol Neurobiol

Specialties Molecular Biology
Neurology

Date 2023 Jul 22

PMID 37480499

Authors

Huixia Geng

Qihang An

Yanshuo Zhang

Yunhang Huang

Lai Wang

Yanming Wang

Affiliations

Soon will be listed here.

Abstract

The deimination or citrullination of arginine residues in the polypeptide chain by peptidylarginine deiminase 4 alters the charge state of the polypeptide chain and affects the function of proteins. It is one of the main ways of protein post-translational modifications to regulate its function. Peptidylarginine deiminase 4 is widely expressed in multiple tissues and organs of the body, especially the central nervous system, and regulates the normal development of organisms. The abnormal expression and activation of peptidylarginine deiminase 4 is an important pathological mechanism for the occurrence and development of central nervous system diseases such as multiple sclerosis, Alzheimer's disease, cerebral ischemia reperfusion injury, and glioblastoma.

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