Septo-hippocampal Dynamics and the Encoding of Space and Time

Overview

Journal Trends Neurosci

Specialty Neurology

Date 2023 Jul 21

PMID 37479632

Authors

Jennifer C Robinson

Jacob H Wilmot

Michael E Hasselmo

Affiliations

Soon will be listed here.

Abstract

Encoding an event in memory requires neural activity to represent multiple dimensions of behavioral experience in space and time. Recent experiments have explored the influence of neural dynamics regulated by the medial septum on the functional encoding of space and time by neurons in the hippocampus and associated structures. This review addresses these dynamics, focusing on the role of theta rhythm, the differential effects of septal inactivation and activation on the functional coding of space and time by individual neurons, and the influence on phase coding that appears as phase precession. We also discuss data indicating that theta rhythm plays a role in timing the internal dynamics of memory encoding and retrieval, as well as the behavioral influences of these neuronal manipulations with regard to memory function.

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