Extracellular Vesicles: a Rising Star for Therapeutics and Drug Delivery

Overview

Journal J Nanobiotechnology

Publisher Biomed Central

Specialty Biotechnology

Date 2023 Jul 20

PMID 37475025

Authors

Shuang Du

Yucheng Guan

Aihua Xie

Zhao Yan

Sijia Gao

Weirong Li

Lang Rao

Xiaojia Chen

Tongkai Chen

Affiliations

Soon will be listed here.

Abstract

Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural carriers for therapeutic agents and drugs, and have many advantages over conventional nanocarriers, including their low immunogenicity, good biocompatibility, natural blood-brain barrier penetration, and capacity for gene delivery. This review first introduces the classification of EVs and then discusses several currently popular methods for isolating and purifying EVs, EVs-mediated drug delivery, and the functionalization of EVs as carriers. Thereby, it provides new avenues for the development of EVs-based therapeutic strategies in different fields of medicine. Finally, it highlights some challenges and future perspectives with regard to the clinical application of EVs.

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