Building the Synaptonemal Complex: Molecular Interactions Between the Axis and the Central Region

Overview

Journal PLoS Genet

Specialty Genetics

Date 2023 Jul 20

PMID 37471284

Authors

Spencer G Gordon

Ofer Rog

Affiliations

Soon will be listed here.

Abstract

The successful delivery of genetic material to gametes requires tightly regulated interactions between the parental chromosomes. Central to this regulation is a conserved chromosomal interface called the synaptonemal complex (SC), which brings the parental chromosomes in close proximity along their length. While many of its components are known, the interfaces that mediate the assembly of the SC remain a mystery. Here, we survey findings from different model systems while focusing on insight gained in the nematode C. elegans. We synthesize our current understanding of the structure, dynamics, and biophysical properties of the SC and propose mechanisms for SC assembly.

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