Biodegradable Polyphosphoester Micelles Act As Both Background-free P Magnetic Resonance Imaging Agents and Drug Nanocarriers

Overview

Journal Nat Commun

Specialty Biology

Date 2023 Jul 19

PMID 37468502

Authors

Olga Koshkina

Timo Rheinberger

Vera Flocke

Anton Windfelder

Pascal Bouvain

Naomi M Hamelmann

Jos M J Paulusse

Hubert Gojzewski

Ulrich Flogel

Frederik R Wurm

Affiliations

Soon will be listed here.

Abstract

In vivo monitoring of polymers is crucial for drug delivery and tissue regeneration. Magnetic resonance imaging (MRI) is a whole-body imaging technique, and heteronuclear MRI allows quantitative imaging. However, MRI agents can result in environmental pollution and organ accumulation. To address this, we introduce biocompatible and biodegradable polyphosphoesters, as MRI-traceable polymers using the P centers in the polymer backbone. We overcome challenges in P MRI, including background interference and low sensitivity, by modifying the molecular environment of P, assembling polymers into colloids, and tailoring the polymers' microstructure to adjust MRI-relaxation times. Specifically, gradient-type polyphosphonate-copolymers demonstrate improved MRI-relaxation times compared to homo- and block copolymers, making them suitable for imaging. We validate background-free imaging and biodegradation in vivo using Manduca sexta. Furthermore, encapsulating the potent drug PROTAC allows using these amphiphilic copolymers to simultaneously deliver drugs, enabling theranostics. This first report paves the way for polyphosphoesters as background-free MRI-traceable polymers for theranostic applications.

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