Maternal Metabolism Influences Neural Tube Closure

Overview

Journal Trends Endocrinol Metab

Specialty Endocrinology

Date 2023 Jul 19

PMID 37468429

Authors

Rachel A Keuls

Richard H Finnell

Ronald J Parchem

Affiliations

Soon will be listed here.

Abstract

Changes in maternal nutrient availability due to diet or disease significantly increase the risk of neural tube defects (NTDs). Because the incidence of metabolic disease continues to rise, it is urgent that we better understand how altered maternal nutrient levels can influence embryonic neural tube development. Furthermore, primary neurulation occurs before placental function during a period of histiotrophic nutrient exchange. In this review we detail how maternal metabolites are transported by the yolk sac to the developing embryo. We discuss recent advances in understanding how altered maternal levels of essential nutrients disrupt development of the neuroepithelium, and identify points of intersection between metabolic pathways that are crucial for NTD prevention.

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