Membrane Vesicles of Lactobacillus Gasseri ATCC 19992 Disrupt Biofilms of Vaginal Pathogens

Overview

Journal Anaerobe

Date 2023 Jul 19

PMID 37467948

Authors

Sameen Khan

Parul Shishpal

Vikrant M Bhor

Affiliations

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Abstract

Membrane vesicles (MVs) are bioactive, nano-sized entities produced by all organisms. MVs of L. gasseri ATCC 19992 were isolated and their effect on the biofilms of vaginal pathogens, G. vaginalis and S. aureus was studied. The L. gasseri MVs resulted in significant disruption of biofilms of the vaginal pathogens.

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Extracellular vesicles from vaginal Gardnerella vaginalis and Mobiluncus mulieris contain distinct proteomic cargo and induce inflammatory pathways.

Joseph A, Anton L, Guan Y, Ferguson B, Mirro I, Meng N NPJ Biofilms Microbiomes. 2024; 10(1):28.

PMID: 38514622 PMC: 10957959. DOI: 10.1038/s41522-024-00502-y.