Nitrogen-Containing 2,3-Dihydroquinazolinone Compounds As Na1.8 Inhibitors for Treating Pain and Cardiovascular Diseases
Overview
Overview
Journal
ACS Med Chem Lett
Publisher
American Chemical Society
Specialty
Chemistry
Date
2023 Jul 19
PMID
37465303
Authors
Authors
Affiliations
Affiliations
Soon will be listed here.
Abstract
Provided herein are novel nitrogen-containing 2,3-dihydroquinazolinone compounds as Na1.8 inhibitors, pharmaceutical compositions, use of such compounds in treating pain and cardiovascular diseases, and processes for preparing such compounds.
References
1.
Suttle A, Wang P, Dias F, Zhang Q, Luo Y, Simmons L
. Sensory Neuron-TRPV4 Modulates Temporomandibular Disorder Pain Via CGRP in Mice. J Pain. 2022; 24(5):782-795.
PMC: 10164682.
DOI: 10.1016/j.jpain.2022.12.001.
View
2.
Zhang X, Zhu L, Wang X, Xia L, Zhang Y
. Advances in the role and mechanism of miRNA in inflammatory pain. Biomed Pharmacother. 2023; 161:114463.
DOI: 10.1016/j.biopha.2023.114463.
View
3.
Sabnis R
. 5-Oxopyrrolidine-3-carboxamides as Na1.8 Inhibitors for Treating Pain Disorders, Cough Disorders, and Acute and Chronic Itch Disorders. ACS Med Chem Lett. 2022; 13(5):761-762.
PMC: 9109472.
DOI: 10.1021/acsmedchemlett.2c00144.
View
4.
Goyal S, Goyal S, Goins A, Alles S
. Plant-derived natural products targeting ion channels for pain. Neurobiol Pain. 2023; 13:100128.
PMC: 10160805.
DOI: 10.1016/j.ynpai.2023.100128.
View
5.
Zhang T, Zhang M, Cui S, Liang W, Jia Z, Guo F
. The core of maintaining neuropathic pain: Crosstalk between glial cells and neurons (neural cell crosstalk at spinal cord). Brain Behav. 2023; 13(2):e2868.
PMC: 9927860.
DOI: 10.1002/brb3.2868.
View