Engineering Tumoral Vascular Leakiness with Gold Nanoparticles

Overview

Journal Nat Commun

Specialty Biology

Date 2023 Jul 17

PMID 37460554

Authors

Magdiel Inggrid Setyawati

Qin Wang

Nengyi Ni

Jie Kai Tee

Katsuhiko Ariga

Pu Chun Ke

Han Kiat Ho

Yucai Wang

David Tai Leong

Affiliations

Soon will be listed here.

Abstract

Delivering cancer therapeutics to tumors necessitates their escape from the surrounding blood vessels. Tumor vasculatures are not always sufficiently leaky. Herein, we engineer therapeutically competent leakage of therapeutics from tumor vasculature with gold nanoparticles capable of inducing endothelial leakiness (NanoEL). These NanoEL gold nanoparticles activated the loss of endothelial adherens junctions without any perceivable toxicity to the endothelial cells. Microscopically, through real time live animal intravital imaging, we show that NanoEL particles induced leakiness in the tumor vessels walls and improved infiltration into the interstitial space within the tumor. In both primary tumor and secondary micrometastases animal models, we show that pretreatment of tumor vasculature with NanoEL particles before therapeutics administration could completely regress the cancer. Engineering tumoral vasculature leakiness represents a new paradigm in our approach towards increasing tumoral accessibility of anti-cancer therapeutics instead of further increasing their anti-cancer lethality.

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