Humoral Immune Responses to Inactivated COVID-19 Vaccine Up to 1 Year in Children with Chronic Hepatitis B Infection

Overview

Journal Front Cell Infect Microbiol

Specialties Cell Biology
Infectious Diseases
Microbiology

Date 2023 Jul 17

PMID 37457966

Authors

Yingzhi Zhou

Zhiwei Chen

Yi He

Xiaorong Peng

Yunan Chang

Aoxue Tan

Hu Li

Dachuan Cai

Peng Hu

Min Chen

Mingli Peng

Hongmei Xu

Hong Ren

Affiliations

Soon will be listed here.

Abstract

Background: Inactivated SARS-CoV-2 vaccination has recently been approved for children aged 3-17 years in China. However, data on long-term humoral responses to inactivated vaccines in children with chronic hepatitis B (CHB) are still limited.

Methods: In this prospective observational study, CHB children after primary inactivated SARS-CoV-2 vaccines were recruited consecutively and followed up for 1 year. CHB adults from another cohort study (NCT05007665) were used as a control. The receptor-binding domain IgG antibody (anti-RBD-IgG), neutralizing antibody (NAb), neutralization against Omicron (BA2.12.1, BA.4 and BA.5), and memory B -cell (MBC) responses were evaluated.

Results: Overall, 115 CHB children and 351 CHB adults were included in this analysis. The antibody titers decreased over the first ~180 days and then plateaued up to 1 year in CHB children. However, lower and faster declines in antibody responses were observed in CHB adults. Interestingly, the seroprevalence of antibodies was still high after over 8 months in CHB children (anti-RBD-IgG [90%] and NAbs [83%]). However, neutralization against Omicron subvariants was significantly reduced in CHB children (-3.68-fold to -8.60-fold). Notably, neutralization against the BA.5 subvariant was obviously diminished in CHB children compared with adults. Moreover, CHB children had similar RBD-specific MBCs but higher RBD-specific atypical MBCs compared with adults.

Conclusion: Inactivated vaccination could elicit more robust and durable antibody responses to the wild-type SARS-CoV-2 strain in CHB children than in CHB adults but showed inferior responses to Omicron subvariants (especially to the BA.5 strain). Hence, new Omicron-related or all-in-one vaccines are needed immediately for CHB children.

References

Goronzy J, Weyand C . T cell development and receptor diversity during aging. Curr Opin Immunol. 2005; 17(5):468-75. DOI: 10.1016/j.coi.2005.07.020. View

Khemiri H, Ayouni K, Triki H, Haddad-Boubaker S . SARS-CoV-2 infection in pediatric population before and during the Delta (B.1.617.2) and Omicron (B.1.1.529) variants era. Virol J. 2022; 19(1):144. PMC: 9452867. DOI: 10.1186/s12985-022-01873-4. View

Xue F, Shen K . COVID-19 in children and the importance of COVID-19 vaccination. World J Pediatr. 2021; 17(5):462-466. PMC: 8476974. DOI: 10.1007/s12519-021-00466-5. View

Wang F, Fan J, Zhang Z, Gao B, Wang H . The global burden of liver disease: the major impact of China. Hepatology. 2014; 60(6):2099-108. PMC: 4867229. DOI: 10.1002/hep.27406. View

Vadrevu K, Reddy S, Jogdand H, Ganneru B, Mirza N, Tripathy V . Immunogenicity and reactogenicity of an inactivated SARS-CoV-2 vaccine (BBV152) in children aged 2-18 years: interim data from an open-label, non-randomised, age de-escalation phase 2/3 study. Lancet Infect Dis. 2022; 22(9):1303-1312. PMC: 9212880. DOI: 10.1016/S1473-3099(22)00307-3. View

Chen Z, Zhu P, Liu Z, Zhu B, Yin G, Ming J . Weakened humoral immune responses of inactivated SARS-CoV-2 vaccines in patients with solid tumors. Cancer Commun (Lond). 2022; 43(2):280-284. PMC: 9877898. DOI: 10.1002/cac2.12368. View

Sutton H, Aye R, Idris A, Vistein R, Nduati E, Kai O . Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans. Cell Rep. 2021; 34(6):108684. PMC: 7873835. DOI: 10.1016/j.celrep.2020.108684. View

Vatti A, Monsalve D, Pacheco Y, Chang C, Anaya J, Gershwin M . Original antigenic sin: A comprehensive review. J Autoimmun. 2017; 83:12-21. DOI: 10.1016/j.jaut.2017.04.008. View

Rivera-Correa J, Mackroth M, Jacobs T, Schulze Zur Wiesch J, Rolling T, Rodriguez A . Atypical memory B-cells are associated with anemia through anti-phosphatidylserine antibodies. Elife. 2019; 8. PMC: 6853636. DOI: 10.7554/eLife.48309. View

10.

Rosa Duque J, Wang X, Leung D, Cheng S, Cohen C, Mu X . Immunogenicity and reactogenicity of SARS-CoV-2 vaccines BNT162b2 and CoronaVac in healthy adolescents. Nat Commun. 2022; 13(1):3700. PMC: 9240007. DOI: 10.1038/s41467-022-31485-z. View

11.

Dowell A, Powell A, Davis C, Scott S, Logan N, Willett B . mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273. Front Immunol. 2022; 13:882515. PMC: 9201026. DOI: 10.3389/fimmu.2022.882515. View

12.

Schulz E, Hodl I, Forstner P, Hatzl S, Sareban N, Moritz M . CD19+IgD+CD27- Naïve B Cells as Predictors of Humoral Response to COVID 19 mRNA Vaccination in Immunocompromised Patients. Front Immunol. 2021; 12:803742. PMC: 8688243. DOI: 10.3389/fimmu.2021.803742. View

13.

Jenks S, Cashman K, Zumaquero E, Marigorta U, Patel A, Wang X . Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus. Immunity. 2018; 49(4):725-739.e6. PMC: 6217820. DOI: 10.1016/j.immuni.2018.08.015. View

14.

Premkumar M, Kedarisetty C . Cytokine Storm of COVID-19 and Its Impact on Patients with and without Chronic Liver Disease. J Clin Transl Hepatol. 2021; 9(2):256-264. PMC: 8111101. DOI: 10.14218/JCTH.2021.00055. View

15.

Liu L, Iketani S, Guo Y, Chan J, Wang M, Liu L . Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2. Nature. 2022; 602(7898):676-681. DOI: 10.1038/s41586-021-04388-0. View

16.

Ogega C, Skinner N, Blair P, Park H, Littlefield K, Ganesan A . Durable SARS-CoV-2 B cell immunity after mild or severe disease. J Clin Invest. 2021; 131(7). PMC: 8011891. DOI: 10.1172/JCI145516. View

17.

Butt A, Dargham S, Loka S, Shaik R, Chemaitelly H, Tang P . Coronavirus Disease 2019 Disease Severity in Children Infected With the Omicron Variant. Clin Infect Dis. 2022; 75(1):e361-e367. PMC: 9047187. DOI: 10.1093/cid/ciac275. View

18.

Klein N, Stockwell M, Demarco M, Gaglani M, Kharbanda A, Irving S . Effectiveness of COVID-19 Pfizer-BioNTech BNT162b2 mRNA Vaccination in Preventing COVID-19-Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Nonimmunocompromised Children and Adolescents Aged 5-17 Years - VISION.... MMWR Morb Mortal Wkly Rep. 2022; 71(9):352-358. PMC: 8893336. DOI: 10.15585/mmwr.mm7109e3. View

19.

Molinos-Albert L, Lorin V, Monceaux V, Orr S, Essat A, Dufloo J . Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers. Nat Commun. 2022; 13(1):1944. PMC: 9001681. DOI: 10.1038/s41467-022-29511-1. View

20.

He T, Zhou Y, Xu P, Ling N, Chen M, Huang T . Safety and antibody response to inactivated COVID-19 vaccine in patients with chronic hepatitis B virus infection. Liver Int. 2022; 42(6):1287-1296. DOI: 10.1111/liv.15173. View