» Articles » PMID: 37448959

Remyelination in Animal Models of Multiple Sclerosis: Finding the Elusive Grail of Regeneration

Overview
Specialty Molecular Biology
Date 2023 Jul 14
PMID 37448959
Authors
Affiliations
Soon will be listed here.
Abstract

Remyelination biology and the therapeutic potential of restoring myelin sheaths to prevent neurodegeneration and disability in multiple sclerosis (MS) has made considerable gains over the past decade with many regeneration strategies undergoing tested in MS clinical trials. Animal models used to investigate oligodendroglial responses and regeneration of myelin vary considerably in the mechanism of demyelination, involvement of inflammatory cells, neurodegeneration and capacity for remyelination. The investigation of remyelination in the context of aging and an inflammatory environment are of considerable interest for the potential translation to progressive multiple sclerosis. Here we review how remyelination is assessed in mouse models of demyelination, differences and advantages of these models, therapeutic strategies that have emerged and current pro-remyelination clinical trials.

Citing Articles

Oligodendrocytes, the Forgotten Target of Gene Therapy.

Ozgur-Gunes Y, Le Stunff C, Bougneres P Cells. 2024; 13(23).

PMID: 39682723 PMC: 11640421. DOI: 10.3390/cells13231973.


Oligodendroglial heterogeneity in health, disease, and recovery: deeper insights into myelin dynamics.

Serneels P, De Schutter J, De Groef L, Moons L, Bergmans S Neural Regen Res. 2024; 20(11):3179-3192.

PMID: 39665821 PMC: 11881716. DOI: 10.4103/NRR.NRR-D-24-00694.


A preclinical mice model of multiple sclerosis based on the toxin-induced double-site demyelination of callosal and cerebellar fibers.

Vejar S, Pizarro I, Pulgar-Sepulveda R, Vicencio S, Polit A, Amador C Biol Res. 2024; 57(1):48.

PMID: 39034395 PMC: 11265164. DOI: 10.1186/s40659-024-00529-7.


The interplay of inflammation and remyelination: rethinking MS treatment with a focus on oligodendrocyte progenitor cells.

Zveik O, Rechtman A, Ganz T, Vaknin-Dembinsky A Mol Neurodegener. 2024; 19(1):53.

PMID: 38997755 PMC: 11245841. DOI: 10.1186/s13024-024-00742-8.

References
1.
Kutzelnigg A, Lucchinetti C, Stadelmann C, Bruck W, Rauschka H, Bergmann M . Cortical demyelination and diffuse white matter injury in multiple sclerosis. Brain. 2005; 128(Pt 11):2705-12. DOI: 10.1093/brain/awh641. View

2.
Kim J, Budde M, Liang H, Klein R, Russell J, Cross A . Detecting axon damage in spinal cord from a mouse model of multiple sclerosis. Neurobiol Dis. 2005; 21(3):626-32. DOI: 10.1016/j.nbd.2005.09.009. View

3.
Duncan G, Simkins T, Emery B . Neuron-Oligodendrocyte Interactions in the Structure and Integrity of Axons. Front Cell Dev Biol. 2021; 9:653101. PMC: 7982542. DOI: 10.3389/fcell.2021.653101. View

4.
Hall S . The effect of injections of lysophosphatidyl choline into white matter of the adult mouse spinal cord. J Cell Sci. 1972; 10(2):535-46. DOI: 10.1242/jcs.10.2.535. View

5.
Lindner M, Fokuhl J, Linsmeier F, Trebst C, Stangel M . Chronic toxic demyelination in the central nervous system leads to axonal damage despite remyelination. Neurosci Lett. 2009; 453(2):120-5. DOI: 10.1016/j.neulet.2009.02.004. View