Extrachromosomal DNA (ecDNA) in Cancer: Mechanisms, Functions, and Clinical Implications

Overview

Journal Front Oncol

Specialty Oncology

Date 2023 Jul 14

PMID 37448518

Authors

Yucheng Dong

Qi He

Xinyu Chen

Fan Yang

Li He

Yongchang Zheng

Affiliations

Soon will be listed here.

Abstract

Extrachromosomal DNA (ecDNA) is circular DNA that plays an important role in the development and heterogeneity of cancer. The rapid evolution of methods to detect ecDNA, including microscopic and sequencing approaches, has greatly enhanced our knowledge of the role of ecDNA in cancer development and evolution. Here, we review the molecular characteristics, functions, mechanisms of formation, and detection methods of ecDNA, with a focus on the potential clinical implications of ecDNA in cancer. Specifically, we consider the role of ecDNA in acquired drug resistance, as a diagnostic and prognostic biomarker, and as a therapeutic target in the context of cancer. As the pathological and clinical significance of ecDNA continues to be explored, it is anticipated that ecDNA will have broad applications in the diagnosis, prognosis, and treatment of patients with cancer.

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