An In Vivo Assessment of the Effect of Hexane Extract from Branches and Its Main Compound, Methyldehydrodieugenol B, on Murine Sponge-Induced Inflammation

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2023 Jul 14

PMID 37446907

Authors

Bruno Antonio Ferreira

Rafael Aparecido Carvalho Souza

Francyelle Borges Rosa de Moura

Tiara da Costa Silva

Tais da Silva Adriano

Eduardo de Faria Franca

Raquel Maria Ferreira de Sousa

Fernanda de Assis Araujo

Joao Henrique Ghilardi Lago

Alberto de Oliveira

Affiliations

Soon will be listed here.

Abstract

The present study aims to explore the anti-inflammatory potential activity of the hexane extract from branches (HEB) of (Lauraceae) and its main compound, methyldehydrodieugenol B, in the inflammatory response induced by a murine implant sponge model. HPLC-ESI/MS analysis of HEB led to the identification of six chemically related neolignans, with methyldehydrodieugenol B as the main compound. An in silico analysis of the pharmacokinetic parameters of the identified compounds suggested moderate solubility but good absorption and biodistribution in vivo. Thus, the treatment of mice with HEB using in vivo assays indicated that HEB promoted pro-inflammatory, antiangiogenic, and antifibrogenic effects, whereas treatment with methyldehydrodieugenol B caused anti-inflammatory, antifibrogenic, and antiangiogenic effects. The obtained results shown the therapeutic potential of HEB and methyldehydrodieugenol B in the treatment of pathologies associated with inflammation and angiogenesis, including chronic wounds.

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